Protein Domain : IPR003558

Type:  Family Name:  Cytolethal distending toxin A/C
Description:  Escherichia coli, Haemophilus spp and Campylobacter spp. all produce a toxin that is seen to cause distension in certain cell lines [, ], which eventually disintegrate and die. This novel toxin, termed cytolethal distending toxin (cdt), has three subunits: A, B and C. Their sizes are approx. 27.7, 29.5 and 19.9kDa respectively [], and they appear to be entirely novel []. Further research on the complete toxin has revealed that it blocks the cell cycle at stage G2, through inactivation of the cyclin-dependent kinase Cdk1, and without induction of DNA breaks. This leads to multipolar abortive mitosis and micronucleation, associated with centrosomal amplification [].The roles of each subunit are unclear, but it is believed that they have separate roles in pathogenicity.This entry represents the A and C subunits. Short Name:  CDtoxinA/C
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2 Child Features

DB identifier Type Name
IPR003559 Family Cytolethal distending toxin C
IPR015957 Family Cytolethal distending toxin A

0 Contains

1 Cross References

Identifier
PF03498

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0009405 IPR003558

1 Ontology Annotations

GO Term Gene Name
GO:0009405 IPR003558

0 Parent Features

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Zosma116g00520.1 A0A0K9Q208 PAC:33181537 Zostera marina 951  
Zosma05g33080 A0A0K9Q208 PAC:50103970 Zostera marina 951  
maker-Fvb6-2-augustus-gene-166.42-mRNA-1 PAC:50470332 Fragaria x ananassa 955  
maker-Fvb6-3-augustus-gene-301.25-mRNA-1 PAC:50501852 Fragaria x ananassa 955  
maker-Fvb6-3-augustus-gene-310.32-mRNA-1 PAC:50500164 Fragaria x ananassa 955  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10777111
            8112838
            10203548