Protein Domain : IPR008958

Type:  Domain Name:  Transglutaminase, C-terminal
Description:  Synonym(s): Protein-glutamine gamma-glutamyltransferase, Fibrinoligase, TGaseTransglutaminases catalyse the post-translational modification of proteins at glutamine residues, with formation of isopeptide bonds. Members of the transglutaminase family usually have three domains: N-terminal (), middle () and C-terminal. The middle domain is usually well conserved, but family members can display major differences in their N- and C-terminal domains, although their overall structure is conserved []. This entry represents the C-terminal domain found in transglutaminases, which consists of an immunoglobulin-like beta-sandwich consisting of seven strands in two sheets with a Greek key topology.The best known transglutaminase is blood coagulation factor XIII, a plasma tetrameric protein composed of two catalytic A subunits and two non-catalytic B subunits. Factor XIII is responsible for cross-linking fibrin chains, thus stabilising the fibrin clot. Protein-glutamine gamma-glutamyltransferases () are calcium-dependent enzymes that catalyse the cross-linking of proteins by promoting the formation of isopeptide bonds between the gamma-carboxyl group of a glutamine in one polypeptide chain and the epsilon-amino group of a lysine in a second polypeptide chain. TGases also catalyse the conjugation of polyamines to proteins [, ]. Short Name:  Transglutaminase_C
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF00927
SSF49309

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0003810 IPR008958
GO:0018149 IPR008958

2 Ontology Annotations

GO Term Gene Name
GO:0003810 IPR008958
GO:0018149 IPR008958

0 Parent Features

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Zosma166g00580.1 A0A0K9PTI4 PAC:33181060 Zostera marina 1186  
PGSC0003DMP400032001 PAC:37432355 Solanum tuberosum 334  
Thint.01G0118300.1.p PAC:40734751 Thinopyrum intermedium 112  
Sphmag01G071100.1.p PAC:41934963 Sphagnum magellanicum 148  
Godar.D05G356500.1.p A0A5D2CNB9 PAC:42582027 Gossypium darwinii 176  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1683845
            1974250
            10411627