4 GO Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003723 | IPR008111 |
| GO:0006396 | IPR008111 |
| GO:0005634 | IPR008111 |
| GO:0005737 | IPR008111 |
4 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003723 | IPR008111 |
| GO:0006396 | IPR008111 |
| GO:0005634 | IPR008111 |
| GO:0005737 | IPR008111 |
| Type: | Family | Name: | RNA-binding motif protein 8 |
| Description: | RNA-binding motif protein 8 (RBM8) contains a putative RNA-binding domain known as an RNA recognition motif (RRM). The RRM motif is found in numerousRNA-binding proteins, including heterogenous nuclear ribonucleoproteins (hnRNPs), and proteins implicated in regulation of alternative splicing. TheRRM is a 90-residue domain that binds single-stranded RNA; the structure consists of four beta-stands and two alpha-helices arranged in an alpha/beta sandwich, with a third helix present in some cases during RNA binding [].Three-dimensional modelling of the RBM8 RRM domain indicates that the sequences fold into an RNA-binding domain, forming a hydrophobic corebetween a beta-sheet and two helices. The human RBM8A protein is ubiquitously expressed; the protein is localised predominantly in the cell nucleus and diffused throughout the cytoplasm[]. It preferentially associates with mRNAs produced by splicing, includingboth nuclear mRNAs and newly exported cytoplasmic mRNAs. Evidence suggests the protein remains associated with spliced mRNAs as a tag to indicate theposition of spliced introns. Human RBM8A protein specicially binds to MAGOH, the human homologue of Drosophila mago nashi, a protein required for normalgerm plasm development in the Drosophila embryo []; a similar associationoccurs with the Drosophila RBM8 protein, Tsunagi [].The RBM8A and RBM8B protein sequences contain a putative bipartate nuclear localisation signal [] at the N terminus, as well a stretch of glycineresidues. In addition, the RRM contained within RBM8A and RBM8B contains one set of the two consensus nucleic acid-binding motifs, RNP-1 and RNP-2,characteristic of heterogeneous nuclear ribonucleoprotein (hnRNP). | Short Name: | RNA-bd_8 |
| GO Term | Gene Name |
|---|---|
| GO:0003723 | IPR008111 |
| GO:0006396 | IPR008111 |
| GO:0005634 | IPR008111 |
| GO:0005737 | IPR008111 |
| GO Term | Gene Name |
|---|---|
| GO:0003723 | IPR008111 |
| GO:0006396 | IPR008111 |
| GO:0005634 | IPR008111 |
| GO:0005737 | IPR008111 |
