1 Found In
| DB identifier | Type | Name |
|---|---|---|
| IPR009203 | Family | Cell wall assembly/cell proliferation-coordinating protein, KNR4 |
| Type: | Domain | Name: | SMI1/KNR4-like domain |
| Description: | This domain is found in the yeast cell wall assembly regulator SMI1 and the cell proliferation protein KNR4 [, ]. Saccharomyces cerevisiae protein Smi1 has a regulatory role in chitin deposition and in cell wall assembly []. KNR4 is believed to connect the PKC1-SLT2 MAPK pathway with cell proliferation. It has been shown to interact with BCK2, a gene involved in cell cycle progression in S. cerevisiae (forming a complex) to allow PKC1 to coordinate the cell cycle (cell proliferation) with cell wall integrity [, ]. KNR4 also interacts with the tyrosine-tRNA synthetase protein encoded by TYS1 and is involved in sporulation process []. Proteins containing this domain also include the animal F-box only protein 3 (FBXO3). In humans, FBXO3 is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex [].Interestingly, Smi1/Knr4 homologues from bacteria are potential immunity proteins in a subset of these contact-dependent inhibitory toxin systems [].Note: previously reported evidence that KNR4 may interact with nuclear matrix-association region [] may be due to an artefact []. | Short Name: | SMI1/KNR4-like_dom |
| DB identifier | Type | Name |
|---|---|---|
| IPR009203 | Family | Cell wall assembly/cell proliferation-coordinating protein, KNR4 |
