Protein Domain : IPR000198

Type:  Domain Name:  Rho GTPase-activating protein domain
Description:  Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation.Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. The active conformation is promoted byguanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs) which stimulate the intrinsic GTPase activity of small G proteins.This entry is a Rho/Rac/Cdc42-like GAP domain, that is found in a wide variety of large,multi-functional proteins [].A number of structure are known for this family [, , ].The domain is composed of seven alpha helices. This domain is also known as the breakpoint cluster region-homology (BH) domain. Short Name:  RhoGAP_dom
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0 Child Features

0 Contains

4 Cross Referencess

Identifier
PF00620
PS50238
SM00324
G3DSA:1.10.555.10

2 Found Ins

DB identifier Type Name
IPR015767 Family Rho GTPase activating protein
IPR017356 Family N-chimaerin

1 GO Annotation

GO Term Gene Name
GO:0007165 IPR000198

1 Ontology Annotations

GO Term Gene Name
GO:0007165 IPR000198

1 Parent Features

DB identifier Type Name
IPR008936 Domain Rho GTPase activation protein

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
442380 D8RSZ1 PAC:15410160 Selaginella moellendorffii 826  
13258 D8RZ76 PAC:15406829 Selaginella moellendorffii 263  
13019 D8SBQ3 PAC:15405213 Selaginella moellendorffii 290  
evm.model.supercontig_13.273 PAC:16407795 Carica papaya 482  
evm.model.supercontig_144.4 PAC:16409049 Carica papaya 478  
evm.model.supercontig_157.59 PAC:16409848 Carica papaya 749  
evm.model.supercontig_195.6 PAC:16412301 Carica papaya 487  
evm.model.supercontig_21.1 PAC:16413369 Carica papaya 707  
evm.model.supercontig_5.2 PAC:16421306 Carica papaya 501  
evm.model.supercontig_9.152 PAC:16428038 Carica papaya 475  
29908.m006240 B9RJV3 PAC:16813055 Ricinus communis 980  
29908.m006244 B9RJV5 PAC:16813057 Ricinus communis 122  
30055.m001575 B9SCV2 PAC:16816206 Ricinus communis 493  
30142.m000632 B9SJ75 PAC:16819460 Ricinus communis 821  
30147.m014262 B9R9W7 PAC:16820273 Ricinus communis 369  
30225.m001728 B9RHR0 PAC:16824216 Ricinus communis 724  
28629.m000558 B9SWG2 PAC:16801313 Ricinus communis 405  
27964.m000351 B9SVE5 PAC:16799639 Ricinus communis 511  
29647.m002044 B9S3Y4 PAC:16804689 Ricinus communis 446  
Cucsa.084720.1 PAC:16956588 Cucumis sativus 481  
Cucsa.185700.1 PAC:16967747 Cucumis sativus 503  
Cucsa.355620.2 PAC:16980196 Cucumis sativus 829  
Cucsa.355620.1 A0A0A0M2Y0 PAC:16980195 Cucumis sativus 870  
Cucsa.160740.1 PAC:16965397 Cucumis sativus 999  
Cucsa.241240.1 PAC:16971002 Cucumis sativus 505  
Cucsa.251420.1 PAC:16971786 Cucumis sativus 730  
Cucsa.259580.1 PAC:16973035 Cucumis sativus 465  
orange1.1g034576m A0A067CZH0 PAC:18094495 Citrus sinensis 90  
orange1.1g002835m A0A067H097 PAC:18107473 Citrus sinensis 875  
orange1.1g003668m A0A067GN31 PAC:18107474 Citrus sinensis 804  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9009196
            9262406
            8962058