| Type: | Domain | Name: | U1 small nuclear ribonucleoprotein of 70kDa N-terminal |
| Description: | This domain is about 90 amino acids in length and is found at the N terminus of U1 small nuclear ribonucleoprotein 70 kDa (U1-70K), which is part of the U1 snRNP (snRNP) complex. U1 snRNP recognises the 5' splice site within precursor messenger RNAs and initiate the assembly of the spliceosome for intron excision.The N-terminal region of U1-70K extends over a distance of 180 A from its RNA binding domain, wraps around the core domain of U1 snRNP consisting of the seven Sm proteins and finally contacts U1-C, which is crucial for 5'-splice-site recognition []. | Short Name: | U1snRNP70_N |
