1 Contains
| DB identifier | Type | Name |
|---|---|---|
| IPR001949 | Conserved_site | NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site |
| Type: | Domain | Name: | NADH-ubiquinone oxidoreductase 51 kDa subunit, FMN-binding domain |
| Description: | NADH:ubiquinone oxidoreductase (complex I) () is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) []. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins []. Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 51 kDa (in mammals), which is the second largest subunit of complex I []. The 51 kDa subunit, as the corresponding bacterial subunit (Nqo1 in Thermus and NuoF in E. coli) [], contains the NADH-binding site, the primary electron acceptor FMN-binding site, and a 4Fe-4S cluster [].This entry represents the FMN-binding domain. | Short Name: | Nuo51_FMN-bd |
| DB identifier | Type | Name |
|---|---|---|
| IPR001949 | Conserved_site | NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site |
