Protein Domain : IPR030217

Type:  Family Name:  Nuclear RNA export factor
Description:  Mex67 is involved in the export of mRNA from the nucleus to the cytoplasm in Saccharomyces cerevisiae []. Vertebrate TAP (also called NXF1 for nuclear RNA export factor 1) is the orthologue of Mex67 []. TAP belongs to a multigene family with conserved modular architecture []. Other members of the family in humans are NXF2, NXF3, and NFX5. Both TAP(NXF1) and NXF2 bind mRNA and display RNA nuclear export activity []. NXF3 also has the ability to export mRNA from the nucleus to the cytoplasm but it uses a different mechanism []. NXF1 and NXF2 are predominantly nuclear, whereas the cytoplasmic presence of NXF3 and NXF5 suggests that they have a different cellular function [, ].Three functional domains of TAP have been characterised: the RNA-binding domain, the Nuclear Transport Factor 2 (NTF2)-like domain, and the ubiquitin-associated (UBA) domain. The RNA-binding domain (RBD) of TAP is located at its amino terminus and is composed of two RNA recognition motifs (RRMs) and one leucine-rich region [, ]. Once bound to mRNA, TAP escorts the messenger ribonucleoprotein (mRNP) to the nuclear pore, where TAP interacts with nucleoporins via the NTF2-like (NTF2L) and UBA domains []. Short Name:  NXF_fam
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2 Child Features

DB identifier Type Name
IPR030216 Family Nuclear RNA export factor 3
IPR030218 Family Nuclear RNA export factor 5

0 Contains

1 Cross References

Identifier
PTHR10662

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Dusal.0199s00017.2.p PAC:33199090 Dunaliella salina 504  
Dusal.0199s00017.1.p PAC:33199089 Dunaliella salina 572  
Dusal.0427s00001.1.p PAC:33194218 Dunaliella salina 103  
Bol017287 PAC:37353486 Brassica oleracea capitata 101  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11073998
            11545741
            11583626
            9660949
            9214641
            11566096
            11724776
            18364396
            10668806