Protein Domain : IPR003365

Type:  Domain Name:  Viral replication-associated protein, N-terminal
Description:  Proteins in this entry are essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep and/or Rep' binds a specific hairpin at the genome origin of replication introducing an endonucleolytic nick within the conserved sequence 5'-AGTATTAC-3'. This initiates rolling circle replication (RCR). Following cleavage, the protein binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Short Name:  Viral_rep_N
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0 Child Features

0 Contains

1 Cross References

Identifier
PF02407

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0016779 IPR003365
GO:0016888 IPR003365
GO:0042624 IPR003365
GO:0006260 IPR003365
GO:0018142 IPR003365

5 Ontology Annotations

GO Term Gene Name
GO:0016779 IPR003365
GO:0016888 IPR003365
GO:0042624 IPR003365
GO:0006260 IPR003365
GO:0018142 IPR003365

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Dusal.0615s00010.1.p PAC:33189858 Dunaliella salina 336  

0 Publications