Protein Domain : IPR004226

Type:  Family Name:  Tubulin binding cofactor A
Description:  The folding pathway of tubulins includes highly specific interactions with a series of cofactors (A, B, C, D and E) after they are released from the eukaryotic chaperonin CCT. Cofactors A and D capture and stabilise tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex, and interaction with cofactor C then causes the release of tubulin poypeptides in the native state [].This entry represents the tubulin-specific chaperone A (TBCA). Mammalian TBCA is involved in tubulin folding []. Budding yeast TBCA, also known as Rbl2, may bind transiently to free beta-tubulin, which then passes into an aggregated form that is not toxic []. Short Name:  CofA_tubulin-bd
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0 Child Features

0 Contains

4 Cross Referencess

Identifier
PTHR21500:SF0
PF02970
PD010430
SSF46988

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0015631 IPR004226
GO:0051082 IPR004226
GO:0007021 IPR004226

3 Ontology Annotations

GO Term Gene Name
GO:0015631 IPR004226
GO:0051082 IPR004226
GO:0007021 IPR004226

0 Parent Features

874 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
59845 D8RW86 PAC:15413213 Selaginella moellendorffii 79  
evm.model.supercontig_117.2 PAC:16406374 Carica papaya 252  
evm.model.supercontig_73.56 PAC:16425636 Carica papaya 113  
30148.m001419 B9SDB0 PAC:16820564 Ricinus communis 113  
30169.m006377 B9RI63 PAC:16821178 Ricinus communis 402  
Cucsa.362540.1 PAC:16980943 Cucumis sativus 172  
Cucsa.143030.1 PAC:16963721 Cucumis sativus 419  
Cucsa.143030.2 PAC:16963722 Cucumis sativus 418  
Cucsa.143030.3 PAC:16963723 Cucumis sativus 416  
Cucsa.143030.4 PAC:16963724 Cucumis sativus 406  
orange1.1g016653m A0A067FPQ0 PAC:18132345 Citrus sinensis 385  
orange1.1g023407m A0A067FT47 PAC:18132347 Citrus sinensis 282  
orange1.1g030215m A0A067DZJ2 PAC:18134258 Citrus sinensis 181  
orange1.1g038806m A0A067E691 PAC:18110934 Citrus sinensis 162  
AT2G30410.1 O04350 PAC:19641752 Arabidopsis thaliana 113  
AT2G30410.2 O04350 PAC:19641753 Arabidopsis thaliana 113  
Thhalv10017954m V4NXC9 PAC:20180533 Eutrema salsugineum 162  
Ciclev10017245m V4TKF8 PAC:20819222 Citrus clementina 112  
Ciclev10033122m V4TG31 PAC:20803263 Citrus clementina 112  
Lus10017932 PAC:23145642 Linum usitatissimum 379  
Lus10027348 PAC:23145444 Linum usitatissimum 386  
Lus10031799 PAC:23180792 Linum usitatissimum 406  
Lus10031896 PAC:23180707 Linum usitatissimum 114  
Lus10031223 PAC:23151114 Linum usitatissimum 446  
Lus10031323 PAC:23150964 Linum usitatissimum 107  
Potri.010G212900.3 PAC:26981474 Populus trichocarpa 435  
Potri.010G212900.2 PAC:26981473 Populus trichocarpa 590  
Potri.013G071100.4 A9PA70 PAC:26993803 Populus trichocarpa 115  
Potri.013G071100.3 PAC:26993806 Populus trichocarpa 99  
Potri.013G071100.1 A9PA70 PAC:26993804 Populus trichocarpa 115  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11739729
            8706133
            8756698