Protein Domain : IPR000643

Type:  Family Name:  Iodothyronine deiodinase
Description:  Iodothyronine deiodinase () (DI) [] is the vertebrate enzyme responsible for the deiodination ofthe prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI areproteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI are known, type II is essential for providing the brain with the appropriate levels of T3 during the criticalperiod of development, and type III is essential for the regulation of thyroid hormone inactivation during embryological development. Short Name:  Iodothyronine_deiodinase
Paste the following link

1 Child Features

DB identifier Type Name
IPR027252 Family Iodothyronine deiodinase I/III

1 Contains

DB identifier Type Name
IPR008261 Active_site Iodothyronine deiodinase, active site

3 Cross Referencess

Identifier
PTHR11781
PF00837
PIRSF001330

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004800 IPR000643
GO:0055114 IPR000643

2 Ontology Annotations

GO Term Gene Name
GO:0004800 IPR000643
GO:0055114 IPR000643

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Dusal.0110s00027.1.p PAC:33194349 Dunaliella salina 189  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7592917