| Type: | Domain | Name: | Misato Segment II tubulin-like domain |
| Description: | The misato protein contains three distinct, conserved domains, segments I, II and III and is involved in the regulation of mitochondrial distribution and morphology []. This entry represents misato segment II.Segments I and III are common to tubulins (), but segment II aligns with myosin heavy chain sequences from Drosophila melanogaster(Fruit fly, ), rabbit (), and human. Segment II of misato is a major contributor to its greater length compared with the various tubulins. The most significant sequence similarities to this 54-amino acid region are from a motif found in the heavy chains of myosins from different organisms. A comparison of segment II with the vertebrate myosin heavy chains reveals that it shares homology with a myosin peptide in the hinge region linking the S2 and LMM domains. Segment II also contains heptad repeats which are characteristic of the myosin tail alpha-helical coiled-coils []. | Short Name: | Misato_II_tubulin-like |
