| Type: | Family | Name: | Phosphoribosylglycinamide synthetase |
| Description: | Phosphoribosylglycinamide synthetase () (GARS) (phosphoribosylamine glycine ligase) [] catalyses the second step in the de novobiosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide: ATP + 5-phosphoribosylamine + glycine = ADP + Pi+ 5'-phosphoribosylglycinamide In bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). In yeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) []. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART []. | Short Name: | PRibGlycinamide_synth |
| DB identifier | Type | Name |
|---|---|---|
| IPR011761 | Domain | ATP-grasp fold |
| IPR011054 | Domain | Rudiment single hybrid motif |
| IPR013815 | Domain | ATP-grasp fold, subdomain 1 |
| IPR013816 | Domain | ATP-grasp fold, subdomain 2 |
| IPR020562 | Domain | Phosphoribosylglycinamide synthetase, N-terminal |
| IPR020560 | Domain | Phosphoribosylglycinamide synthetase, C-domain |
| IPR020561 | Domain | Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain |
| IPR020559 | Conserved_site | Phosphoribosylglycinamide synthetase, conserved site |
