Type: | Domain | Name: | NTP pyrophosphohydrolase-like domain |
Description: | This entry represents a putative pyrophosphohydrolase-like domain. It is a variant of the all-alpha-helical NTP pyrophosphatase fold family and contains an unusual intertwined swapping of helical segments, resulting in an obligatory dimer that cannot dissociate without unfolding of the monomers. This novel "linked dimer" defines a new subfamily of the alpha-helical NTP pyrophosphatase fold and is distinct from other previously observed domain-swapped dimers []. | Short Name: | NTP_PyroPHydrolase-like_dom |