Protein Domain : IPR000884

Type:  Repeat Name:  Thrombospondin type-1 (TSP1) repeat
Description:  Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of cell interactions in vertebrates. They are divided into two subfamilies, A and B, according to their overall molecular organisation. The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. They are assembled as trimer. The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are distinct in that they contain unique N-terminal regions, lack the VWFC domain and TSP1 repeats, contain four copies of EGF-like domains, and are assembled as pentamers []. EGF, TSP3 repeats and the C-terminal domain are thus the hallmark of a thrombospondin.This repeat was first described in 1986 by Lawler and Hynes []. It was found in the thrombospondin protein where it is repeated 3 times. Now a number of proteins involved in the complement pathway (properdin, C6, C7, C8A, C8B, C9) [] as well as extracellular matrix protein like mindin, F-spondin [], SCO-spondin and even the circumsporozoite surface protein 2 and TRAP proteins of Plasmodium [, ] contain one or more instance of this repeat.It has been involved in cell-cell interaction, inhibition of angiogenesis [] andapoptosis [].The intron-exon organisation of the properdin gene confirms the hypothesis that the repeat might have evolved by a process involving exon shuffling [].A study of properdin structure provides some information about the structure of the thrombospondin type I repeat []. Short Name:  TSP1_rpt
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0 Child Features

0 Contains

4 Cross Referencess

Identifier
PF00090
PS50092
SM00209
SSF82895

10 Found Ins

DB identifier Type Name
IPR013273 Family Peptidase M12B, ADAM-TS
IPR001862 Family Membrane attack complex component/perforin/complement C9
IPR013275 Family Peptidase M12B, ADAM-TS2
IPR013274 Family Peptidase M12B, ADAM-TS1
IPR012395 Family IGFBP-related, CNN
IPR008077 Family GPCR, family 2, brain-specific angiogenesis inhibitor
IPR013276 Family Peptidase M12B, ADAM-TS5
IPR015455 Family Thrombospondin-2
IPR003067 Family Plasmodium circumsporozoite protein
IPR013277 Family Peptidase M12B, ADAM-TS8

0 GO Annotation

0 Ontology Annotations

0 Parent Features

141 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
417729 D8S3E8 PAC:15406027 Selaginella moellendorffii 868  
62114 I0Z223 PAC:27387222 Coccomyxa subellipsoidea C-169 1068  
57035 I0YRU6 PAC:27386110 Coccomyxa subellipsoidea C-169 1468  
39345 I0ZAU6 PAC:27388929 Coccomyxa subellipsoidea C-169 958  
48081 C1MZE5 PAC:27344074 Micromonas pusilla CCMP1545 1361  
38355 C1MJR7 PAC:27343137 Micromonas pusilla CCMP1545 1450  
193099 C1MMM0 PAC:27347468 Micromonas pusilla CCMP1545 754  
47261 C1MT37 PAC:27341756 Micromonas pusilla CCMP1545 3986  
57919 C1E459 PAC:27400228 Micromonas sp RCC299 169  
100485 C1E642 PAC:27395714 Micromonas sp RCC299 892  
59232 C1E833 PAC:27402251 Micromonas sp RCC299 1506  
24559 A4RXI9 PAC:27416588 Ostreococcus lucimarinus 1163  
Cre10.g437300.t1.1 A0A2K3DA98 PAC:30790333 Chlamydomonas reinhardtii 4089  
SapurV1A.0120s0300.2.p PAC:31413443 Salix purpurea 445  
Spipo8G0031800 PAC:31511436 Spirodela polyrhiza 173  
evm_27.model.AmTr_v1.0_scaffold00052.23 U5D2A1 PAC:31574116 Amborella trichopoda 142  
GSMUA_AchrUn_randomP07050_001 PAC:32295279 Musa acuminata 372  
GSMUA_Achr6P01620_001 PAC:32319646 Musa acuminata 267  
Manes.11G048900.1.p A0A2C9UZR8 PAC:32355338 Manihot esculenta 269  
Pahal.D01793.2 PAC:32498185 Panicum hallii 320  
Pahal.D01793.1 A0A2S3HU10 PAC:32498184 Panicum hallii 356  
Sphfalx0038s0092.1.p PAC:32603503 Sphagnum fallax 206  
Sphfalx0038s0092.2.p PAC:32603504 Sphagnum fallax 189  
Sphfalx0173s0007.1.p PAC:32631909 Sphagnum fallax 1148  
Sphfalx0185s0022.1.p PAC:32619177 Sphagnum fallax 259  
Sevir.5G230100.1.p A0A4U6UGL1 PAC:32669526 Setaria viridis 265  
Seita.5G223000.1.p K3XKZ8 PAC:32681094 Setaria italica 265  
Seita.5G223000.2.p A0A368R7H7 PAC:32681095 Setaria italica 197  
Pp3c20_13790V3.2.p A9SMC7 PAC:32946760 Physcomitrium patens 263  
Pp3c20_13790V3.1.p A9SMC7 PAC:32946759 Physcomitrium patens 263  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2459396
            2430973
            10508153
            1501644
            1417780
            1868073
            10409509
            9135017
            10500044
            11687483