Protein Domain : IPR003898

Type:  Family Name:  Bordetella pertussis toxin A
Description:  A large group of bacterial exotoxins are referred to as "A/B toxins", essentially because they are formed from two subunits []. The "A" subunitpossesses enzyme activity, and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit [].Bordetella pertussisis the causative agent of whooping cough, and is a Gram-negative aerobic coccus. Its major virulence factor is the pertussis toxin, an A/B exotoxin that mediates both colonisation and toxaemic stages of the the disease [, ]. Recombinant, inactive forms of the 5 subunits that make up the toxin have proven to be good vaccines.The S1 ("A") subunit of pertussis toxin causes the characteristic sound of the "whoop" in whooping cough. It achieves this through ADP-ribosylation of host Gi alpha-units, an adenylate cyclase inhibitor [, ]. Uninhibited, this enzyme produces elevated levels of cAMP, leading to increased cell exudate and inflammation in the lungs [].The crystal structure of pertussis toxin has been determined to 2.9A resolution []. The catalytic A-subunit (S1) shares structural similarity with other ADP-ribosylating bacterial toxins, although differences in the C-terminal portion explain its unique activation mechanism. Despite itsheterogeneous subunit composition, the structure of the cell-binding B-oligomer (S2, S3, two copies of S4, and S5) resembles the symmetricalB-pentamers of the cholera and shiga toxin families, but it interacts differently with the A-subunit and there is virtually no sequence similarity between B-subunits of the different toxins. Short Name:  Borpert_toxA
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF02917
PR01395

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003950 IPR003898
GO:0009405 IPR003898
GO:0005576 IPR003898

3 Ontology Annotations

GO Term Gene Name
GO:0003950 IPR003898
GO:0009405 IPR003898
GO:0005576 IPR003898

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
417769 D8S3K0 PAC:15406119 Selaginella moellendorffii 251  
Phacu.CVR.002G261100.1 PAC:45478230 Phaseolus acutifolius 216  
Phacu.WLD.002G257800.1 PAC:45540665 Phaseolus acutifolius WLD 304  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8225592
            3704651
            2873570
            2737291
            8075982