Protein Domain : IPR009051

Type:  Domain Name:  Alpha-helical ferredoxin
Description:  The alpha-helical ferredoxin domain contains two Fe4-S4 clusters, typical of bacterial ferredoxin. Iron-sulphur proteins play an important role in electron transfer processes and in various enzymatic reactions. In eukaryotes, the mitochondria are the major site of Fe-S cluster biosynthesis in the cell, used for the assembly of mitochondrial and non-mitochondrial Fe-S proteins. The alpha-helical ferredoxin domain is present in several proteins involved in redox reactions, including the C-terminal of the respiratory proteins succinate dehydrogenase (SQR) in bacteria/mitochondria, and fumarate reductase (QFR) in bacteria. SQR is analogous to the mitochondrial respiratory complex II, and is involved in the electron transport pathway from succinate as a donor to the acceptor ubiquinone. SQR helps prevent the formation of reactive oxygen species and is used during aerobic respiration, whereas QFR does not and, consequently, is used to catalyse the final step of anaerobic respiration using the acceptor fumarate [].The alpha-helical ferredoxin domain is also present in the N-terminal of the cytosolic protein dihydropyrimidine dehydrogenase, (DPD) which catalyses the NADPH-dependent, rate-limiting step in pyrimidine degradation, converting pyrimidines to 5,6-dihydro compounds []. DPD catalysis involves electron transfer from NADPH to the substrate via the Fe4-S4 centre and FAD. In mammals, this pathway produces the neurotransmitter beta-alanine. Short Name:  Helical_ferredxn

0 Child Features

1 Contains

DB identifier Type Name
IPR017900 Conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site

1 Cross References

Identifier
SSF46548

5 Found Ins

DB identifier Type Name
IPR010226 Family NADH-quinone oxidoreductase, chain I
IPR004453 Family Epoxyqueuosine reductase QueG
IPR004460 Family CO dehydrogenase/acetyl-CoA synthase complex alpha subunit
IPR014259 Family Sulphite reductase, subunit A
IPR014283 Family Ferredoxin III 4[4Fe-4S], nif-specific

1 GO Annotation

GO Term Gene Name
GO:0051536 IPR009051

1 Ontology Annotations

GO Term Gene Name
GO:0051536 IPR009051

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
108358 D8S3V0 PAC:15422830 Selaginella moellendorffii 217  
57580 D8S953 PAC:15405008 Selaginella moellendorffii 234  
439142 D8R2R8 PAC:15421672 Selaginella moellendorffii 2144  
82638 D8R0V1 PAC:15412741 Selaginella moellendorffii 258  
118126 D8SIL6 PAC:15406153 Selaginella moellendorffii 248  
85593 D8R553 PAC:15420861 Selaginella moellendorffii 248  
86191 D8R556 PAC:15420709 Selaginella moellendorffii 248  
158084 D8STB8 PAC:15412060 Selaginella moellendorffii 2065  
evm.model.supercontig_130.56 PAC:16407962 Carica papaya 281  
evm.model.supercontig_283.8 PAC:16416051 Carica papaya 305  
evm.model.supercontig_3.65 PAC:16416850 Carica papaya 2012  
30169.m006499 B9RII5 PAC:16821299 Ricinus communis 2215  
29633.m000905 B9SLS5 PAC:16804165 Ricinus communis 284  
28745.m000035 B9T7U2 PAC:16801628 Ricinus communis 313  
Cucsa.040650.2 PAC:16952776 Cucumis sativus 1859  
Cucsa.040650.1 PAC:16952775 Cucumis sativus 2202  
Cucsa.029520.1 A0A0A0KUA7 PAC:16952200 Cucumis sativus 293  
Cucsa.156220.1 A0A0A0LBZ3 PAC:16964857 Cucumis sativus 277  
orange1.1g045926m A0A067EN50 PAC:18128301 Citrus sinensis 302  
orange1.1g023670m A0A067DRR6 PAC:18131515 Citrus sinensis 279  
orange1.1g026956m A0A067DVV7 PAC:18131516 Citrus sinensis 230  
orange1.1g000265m A0A067E773 PAC:18105075 Citrus sinensis 1760  
orange1.1g000266m A0A067E773 PAC:18105074 Citrus sinensis 1760  
AT5G40650.1 Q8LB02 PAC:19666862 Arabidopsis thaliana 280  
AT5G53460.1 Q9LV03 PAC:19667700 Arabidopsis thaliana 2208  
AT5G53460.3 Q9LV03 PAC:19667702 Arabidopsis thaliana 2208  
AT5G53460.2 Q9LV03 PAC:19667701 Arabidopsis thaliana 2208  
AT5G65165.1 Q9FJP9 PAC:19666411 Arabidopsis thaliana 309  
AT3G27380.1 Q8LBZ7 PAC:19658637 Arabidopsis thaliana 279  
AT3G27380.2 Q8LBZ7 PAC:19658638 Arabidopsis thaliana 279  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11850430
            11796730