Protein Domain : IPR013346

Type:  Domain Name:  Ribonucleotide reductase, class I , alpha subunit
Description:  This entry represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen []. Escherichia colicontains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains [, ]). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. Short Name:  NrdE_NrdA
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0 Child Features

1 Contains

DB identifier Type Name
IPR013509 Domain Ribonucleotide reductase large subunit, N-terminal

1 Cross References

Identifier
TIGR02506

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0055114 IPR013346

1 Ontology Annotations

GO Term Gene Name
GO:0055114 IPR013346

1 Parent Features

DB identifier Type Name
IPR000788 Domain Ribonucleotide reductase large subunit, C-terminal

803 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
109545 D8S623 PAC:15404947 Selaginella moellendorffii 786  
evm.model.supercontig_72.46 PAC:16425547 Carica papaya 791  
29863.m001065 B9SE90 PAC:16811687 Ricinus communis 810  
28225.m000019 B9T7V1 PAC:16800365 Ricinus communis 776  
Cucsa.101340.2 PAC:16958685 Cucumis sativus 750  
Cucsa.101340.1 A0A0A0KJ45 PAC:16958684 Cucumis sativus 807  
orange1.1g003602m A0A067ETE3 PAC:18096150 Citrus sinensis 808  
orange1.1g003575m A0A067H882 PAC:18091914 Citrus sinensis 810  
orange1.1g003561m A0A067DM21 PAC:18093900 Citrus sinensis 811  
AT2G21790.1 Q9SJ20 PAC:19640376 Arabidopsis thaliana 816  
Thhalv10024430m V4MDC2 PAC:20194407 Eutrema salsugineum 817  
Thhalv10027643m V4L9Y3 PAC:20189947 Eutrema salsugineum 817  
Ciclev10000379m V4TDK4 PAC:20788814 Citrus clementina 755  
Ciclev10027252m V4SQG8 PAC:20800948 Citrus clementina 777  
Ciclev10030727m V4VDZ9 PAC:20802357 Citrus clementina 808  
Lus10033526 PAC:23143479 Linum usitatissimum 812  
Lus10020845 PAC:23177989 Linum usitatissimum 813  
Lus10018867 PAC:23144685 Linum usitatissimum 797  
Potri.005G087300.1 A0A2K2ADT2 PAC:27030023 Populus trichocarpa 820  
Potri.005G087300.2 PAC:27030024 Populus trichocarpa 813  
Potri.005G194900.1 B9H7U7 PAC:27030662 Populus trichocarpa 810  
Potri.007G076700.1 PAC:27014507 Populus trichocarpa 838  
Potri.007G076700.2 B9HGC7 PAC:27014508 Populus trichocarpa 812  
Potri.007G076700.3 PAC:27014509 Populus trichocarpa 784  
Potri.007G076700.4 PAC:27014510 Populus trichocarpa 751  
Gorai.002G149900.1 A0A0D2QDA9 PAC:26793864 Gossypium raimondii 807  
Gorai.002G149900.2 A0A0D2MBA6 PAC:26793865 Gossypium raimondii 707  
Gorai.003G048900.2 A0A0D2QNE5 PAC:26799155 Gossypium raimondii 746  
Gorai.003G048900.3 A0A0D2RGU2 PAC:26799156 Gossypium raimondii 707  
Gorai.003G048900.1 A0A0D2QFR9 PAC:26799154 Gossypium raimondii 807  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8052308
            11807048
            8820648