Type: | Family | Name: | 4-hydroxybenzoate polyprenyltransferase |
Description: | Members of this family show a broad specificity for prenyl diphosphates, accepting substrates of different chain lengths. Genes coding for these enzymes have been identified in many organisms, and are mostly responsible for ubiquinone (UQ) biosynthesis [, , ]. 4-hydroxybenzoate solanesyltransferase from cyanobacteria displays a broad specificity with regard to the prenyl donor substrate and uses not only solanesyl diphosphate, but also a number of shorter-chain prenyl diphosphates []. One exception is LePGT1 (Lithospermum erythrorhizon 4-hydroxybenzoic acid geranyltransferase), which only accepts GPP (geranyl diphosphate) and is involved in the biosynthesis of a red naphthoquinone, shikonin, a plant secondary metabolite []. LePGT1 was reported to be the key regulatory enzyme of shikonin biosynthesis [] and is not relevant to the formation of UQ []. | Short Name: | HB_polyprenyltransferase |