Protein Domain : IPR007204

Type:  Family Name:  Actin-related protein 2/3 complex subunit 3
Description:  Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures []. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family protein []. Arp2 and Arp3 are thought to be brought together after activation, forming an actin-like nucleus for actin monomers to bind and create a new actin filament. In the absence of an activating protein, Arp2/3 shows very little nucleation activity. Recent research has focused on the binding and hydrolysis of ATP by Arp2 and Arp3 [], and crystal structures of the Arp2/3 complex have been solved [].The human complex consists of Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. This family represents the ARPC3/p21-ARC subunit. Short Name:  ARPC3
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0 Child Features

0 Contains

5 Cross Referencess

Identifier
PTHR12391
PF04062
PIRSF016315
G3DSA:1.10.1760.10
SSF69060

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0030833 IPR007204
GO:0034314 IPR007204
GO:0005856 IPR007204
GO:0005885 IPR007204

4 Ontology Annotations

GO Term Gene Name
GO:0030833 IPR007204
GO:0034314 IPR007204
GO:0005856 IPR007204
GO:0005885 IPR007204

0 Parent Features

696 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
230335 D8RWB1 PAC:15413114 Selaginella moellendorffii 175  
evm.model.supercontig_103.41 PAC:16404926 Carica papaya 1449  
evm.model.supercontig_277.15 PAC:16415807 Carica papaya 174  
27394.m000348 B9SXP0 PAC:16798221 Ricinus communis 154  
Cucsa.132460.1 A0A0A0LI55 PAC:16962563 Cucumis sativus 174  
Cucsa.132460.2 A0A0A0LI55 PAC:16962564 Cucumis sativus 174  
Cucsa.132460.3 PAC:16962565 Cucumis sativus 150  
orange1.1g030601m A0A067G1G4 PAC:18126037 Citrus sinensis 174  
AT1G60430.2 Q1ECJ7 PAC:19651660 Arabidopsis thaliana 174  
AT1G60430.1 Q1ECJ7 PAC:19651659 Arabidopsis thaliana 174  
Thhalv10023668m V4KPY8 PAC:20200953 Eutrema salsugineum 233  
Ciclev10009685m V4UUP8 PAC:20794091 Citrus clementina 174  
Lus10029603 PAC:23151947 Linum usitatissimum 284  
Lus10018909 PAC:23144697 Linum usitatissimum 174  
Lus10006335 PAC:23178338 Linum usitatissimum 190  
Potri.006G063400.1 PAC:27006585 Populus trichocarpa 253  
Potri.018G123100.1 U7DZC2 PAC:27010227 Populus trichocarpa 174  
Gorai.004G108300.2 A0A0D2MWL4 PAC:26773752 Gossypium raimondii 174  
Gorai.004G108300.6 A0A0D2MWL4 PAC:26773753 Gossypium raimondii 174  
Gorai.004G108300.11 A0A0D2MWL4 PAC:26773756 Gossypium raimondii 174  
Gorai.004G108300.12 A0A0D2MWL4 PAC:26773754 Gossypium raimondii 174  
Gorai.004G108300.4 A0A0D2QVJ5 PAC:26773757 Gossypium raimondii 164  
Gorai.004G108300.5 A0A0D2QVJ5 PAC:26773758 Gossypium raimondii 164  
Gorai.004G108300.7 A0A0D2P9X5 PAC:26773760 Gossypium raimondii 160  
Gorai.004G108300.9 A0A0D2RX22 PAC:26773762 Gossypium raimondii 137  
Gorai.004G108300.3 A0A0D2QVJ5 PAC:26773759 Gossypium raimondii 164  
Gorai.004G108300.8 A0A0D2P9X5 PAC:26773761 Gossypium raimondii 160  
Gorai.004G108300.1 A0A0D2R2G4 PAC:26773751 Gossypium raimondii 188  
Gorai.004G108300.10 A0A0D2MWL4 PAC:26773755 Gossypium raimondii 174  
Gorai.009G014900.1 A0A0D2TAZ9 PAC:26765368 Gossypium raimondii 178  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9889097
            15505213
            9600938
            11752435