1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR014719 | Domain | Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
| Type: | Domain | Name: | Adaptor protein ClpS, core |
| Description: | In the bacterial cytosol, ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. ClpS directly influences the ClpAP machine by binding to the N-terminal domain of the chaperone ClpA. The degradation of ClpAP substrates, both SsrA-tagged proteins and ClpA itself, is specifically inhibited by ClpS. ClpS modifies ClpA substrate specificity, potentially redirecting degradation by ClpAP toward aggregated proteins [].ClpS is a small alpha/beta protein that consists of three alpha-helices connected to three antiparallel beta-strands []. The protein has a globular shape, with a curved layer of three antiparallel alpha-helices over a twisted antiparallel beta-sheet. Dimerization of ClpS may occur through its N-terminal domain. This short extended N-terminal region in ClpS is followed by the central seven-residue beta-strand, which is flanked by two other beta-strands in a small beta-sheet. | Short Name: | ClpS_core |
| DB identifier | Type | Name |
|---|---|---|
| IPR014719 | Domain | Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
