Protein Domain : IPR004865

Type:  Domain Name:  Homogeneously-staining region
Description:  The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerisation domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region) []. This domain can also be found in Vertebrate AutoImmune REgulator (AIRE) protein, a transcription regulator predominantly expressed in thymus medullary epithelial cells which also localises to nuclear dots []. The HSR domain, which has also been named ASS (AIRE, Sp-100 and Sp140) domain [], can be found alone or in association with other domains, such as SAND , PHD finger and Bromo , The HSR domain is predicted to be predominantly alpha-helical [, , ]. Short Name:  HSR_dom
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF03172
PS51414

1 Found In

DB identifier Type Name
IPR008087 Family Autoimmune regulator, AIRE

1 GO Annotation

GO Term Gene Name
GO:0005634 IPR004865

1 Ontology Annotations

GO Term Gene Name
GO:0005634 IPR004865

0 Parent Features

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Thhalv10004718m V4KJ67 PAC:20199032 Eutrema salsugineum 289  
Thhalv10004392m V4MIQ5 PAC:20199030 Eutrema salsugineum 381  
Thhalv10004398m V4MIQ5 PAC:20199031 Eutrema salsugineum 381  
Spipo26G0009100 PAC:31515222 Spirodela polyrhiza 781  
HanXRQChr16g0499841 A0A251RVH0 PAC:40301336 Helianthus annuus 226  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9697411
            10049735
            10212234
            24275490