Protein Domain : IPR011259

Type:  Domain Name:  Ezrin/radixin/moesin, C-terminal
Description:  The ERM family consists of three closely-related proteins, ezrin, radixin and moesin [].Ezrin was first identified as a constituent of microvilli [], radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions [], and moesin as a heparinbinding protein []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2)is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain; an extended alpha-helical domain; and acharged C-terminal domain []. Ezrin, radixin and merlin also contain a polyproline region betweenthe helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins crosslink actin filaments withplasma membranes. They co-localise with CD44 at actin filament-plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains[]. Short Name:  ERM_C_dom
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0 Child Features

1 Contains

DB identifier Type Name
IPR008954 Domain Moesin tail domain

1 Cross References

Identifier
PF00769

3 Found Ins

DB identifier Type Name
IPR000798 Family Ezrin/radixin/moesin-like
IPR011174 Family Ezrin/radixin/moesin
IPR015788 Family Moesin/ezrin/radixin homologue 2

3 GO Annotations

GO Term Gene Name
GO:0008092 IPR011259
GO:0005737 IPR011259
GO:0019898 IPR011259

3 Ontology Annotations

GO Term Gene Name
GO:0008092 IPR011259
GO:0005737 IPR011259
GO:0019898 IPR011259

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Thhalv10011750m V4KRG4 PAC:20185030 Eutrema salsugineum 231  
Cre02.g097300.t2.1 A0A2K3E222 PAC:30786418 Chlamydomonas reinhardtii 282  
Lsat_1_v5_gn_9_50221.1 A0A2J6KWD0 PAC:38926658 Lactuca sativa 725  
Lsat_1_v5_gn_9_50181.3 PAC:38923265 Lactuca sativa 710  
Lsat_1_v5_gn_9_50181.1 A0A2J6KWD8 PAC:38923264 Lactuca sativa 718  
Luann.0038s0071.1.p PAC:39403529 Lunaria annua 397  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3046603
            6885906
            2500445
            9048483