Protein Domain : IPR002606

Type:  Family Name:  Riboflavin kinase, bacterial
Description:  Riboflavin is converted into catalytically active cofactors (FAD and FMN) by the actions of riboflavin kinase (), which converts it into FMN, and FAD synthetase (), which adenylates FMN to FAD. Eukaryotes usually have two separate enzymes, while most prokaryotes have a single bifunctional protein that can carry out both catalyses, although exceptions occur in both cases. While eukaryotic monofunctional riboflavin kinase is orthologous to the bifunctional prokaryotic enzyme [], the monofunctional FAD synthetase differs from its prokaryotic counterpart, and is instead related to the PAPS-reductase family []. The bacterial FAD synthetase that is part of the bifunctional enzyme has remote similarity to nucleotidyl transferases and, hence, it may be involved in the adenylylation reaction of FAD synthetases [].This entry represents the bacterial bifunctional form of riboflavin kinase. Short Name:  Riboflavin_kinase_bac
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0 Child Features

3 Contains

DB identifier Type Name
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR015864 Domain FAD synthetase
IPR015865 Domain Riboflavin kinase domain, bacterial/eukaryotic

2 Cross Referencess

Identifier
PIRSF004491
TIGR00083

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003919 IPR002606
GO:0008531 IPR002606
GO:0009231 IPR002606

3 Ontology Annotations

GO Term Gene Name
GO:0003919 IPR002606
GO:0008531 IPR002606
GO:0009231 IPR002606

1 Parent Features

DB identifier Type Name
IPR023468 Family Riboflavin kinase

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1001119m.p PAC:33620258 Brachypodium distachyon Pangenome 1637  
Brdisv1pangenome1009117m.p PAC:33655990 Brachypodium distachyon Pangenome 1610  
Brdisv1BdTR11A1009828m.p PAC:35654558 Brachypodium distachyon BdTR11a 1637  
Brdisv1BdTR11A1040519m.p PAC:35692126 Brachypodium distachyon BdTR11a 1610  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12517446
            14580199
            17049878