Protein Domain : IPR012782

Type:  Family Name:  Acetolactate synthase, catabolic
Description:  Acetolactate synthase is a thiamin pyrophosphate-dependent enzyme that combines two molecules of pyruvate to yield 2-acetolactate with the release of CO2. It exists in two distinct forms that have different properties, though they are clearly related [, ]. The biosynthetic form, found in plants, fungi and bacteria, is involved in the biosynthesis of branched-chain amino acids and contains non-catalytic FAD. The catabolic form is found only in some bacteria, participates in butanediol fermentation, and does not contain FAD.This entry represents the catabolic form of acetolactate synthase, generally found in species that posses acetolactate decarboxylase, which is often encoded in the same operon. The enzyme is thought to be a homotetramer, though this has not conclusively been shown. Each monomer consists of three distinct domains, designated, starting from the N terminus, as alpha, beta and gamma []. The core of the alpha and gamma domains is a six-stranded parallel beta sheet surrounded by alpha helices, while the the beta domain forms a double Rossman fold. The thiamin pyrophosphate cofactor has an unusual conformation that has not been seen in other enzymes using this cofactor, including the biosynthetic form of acetolactate synthase. The active site is located in a funnel at the dimer interface, bordered by residues fromall three domains. Short Name:  Acetolactate_synth_catblc
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0 Child Features

3 Contains

DB identifier Type Name
IPR011766 Domain Thiamine pyrophosphate enzyme, C-terminal TPP-binding
IPR012000 Domain Thiamine pyrophosphate enzyme, central domain
IPR012001 Domain Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain

1 Cross References

Identifier
TIGR02418

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0000287 IPR012782
GO:0003984 IPR012782
GO:0030976 IPR012782
GO:0034077 IPR012782

4 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR012782
GO:0003984 IPR012782
GO:0030976 IPR012782
GO:0034077 IPR012782

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1004653m.p PAC:33655483 Brachypodium distachyon Pangenome 559  
Brdisv1pangenome1008926m.p PAC:33621111 Brachypodium distachyon Pangenome 544  
Brdisv1BdTR11A1031174m.p PAC:35675397 Brachypodium distachyon BdTR11a 559  
Brdisv1BdTR11A1039958m.p PAC:35692572 Brachypodium distachyon BdTR11a 521  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9099862
            2675968
            14557277