Protein Domain : IPR012839

Type:  Family Name:  Glycyl radical enzyme activase
Description:  This subset of the radical-SAM domain includes a number of probable activating proteins acting on different enzymes all requiring an amino-acid-centred radical. The closest relatives to this family are the pyruvate-formate lyase activating enzyme (PflA, , ) and the anaerobic ribonucleotide reductase activating enzyme (). Included within this subfamily are activators of hydroxyphenyl acetate decarboxylase (HdpA, []), benzylsuccinate synthase (BssD, []), gycerol dehydratase (DhaB2, []) as well as enzymes annotated in Escherichia colias activators of different isozymes of pyruvate-formate lyase (PFLC and PFLE) however, these appear to lack characterisation and may activate enzymes with distinctive functions. Most of the sequence-level variability between these forms is concentrated within an N-terminal domain, which follows a conserved group of three cysteines and contains a variable pattern of 0 to 8 additional cysteines. Short Name:  Glycyl_radical_activase
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3 Child Features

DB identifier Type Name
IPR023880 Family Benzylsuccinate synthase activating enzyme
IPR023912 Family Glycyl radical enzyme activase, YjjW, bact
IPR030905 Family Choline TMA-lyase-activating enzyme

2 Contains

DB identifier Type Name
IPR007197 Domain Radical SAM
IPR001989 Conserved_site Radical-activating enzyme, conserved site

2 Cross Referencess

Identifier
PIRSF000371
TIGR02494

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0016491 IPR012839
GO:0006006 IPR012839
GO:0055114 IPR012839

3 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR012839
GO:0006006 IPR012839
GO:0055114 IPR012839

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1005578m.p PAC:33658098 Brachypodium distachyon Pangenome 539  
Brdisv1BdTR11A1029421m.p PAC:35682054 Brachypodium distachyon BdTR11a 539  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15153112
            12704244
            14735297