Protein Domain : IPR014388

Type:  Family Name:  3-oxoacid CoA-transferase
Description:  CoA-transferases catalyse the reversible transfer of of coenzyme A from CoA-thioesters to free acids, and can be divided into three families []. Family I includes transferases for 3-oxoacids (, ), short-chain fatty acids (, ) and glutaconate (). Most of the family I enzymes use acetyl-CoA or succinyl-CoA as CoA donors, and are composed of two separate polypeptides, subunits A and B, which generally aggregate as heterodimers or heterotetramers. The eukaryotic enzymes, however, are generally composed of a single two-domain polypetide representing a fusion of the A and B subunits. The transfer of CoA from one substrate to another occurs via a ping pong mechanism which involves the formation of thioester bond between CoA and a conserved glutamate residue at the active site of the enzyme [].This entry represents a family of 3-oxoacid CoA-transferases. Short Name:  3-oxoacid_CoA-transferase
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0 Child Features

2 Contains

DB identifier Type Name
IPR012791 Domain 3-oxoacid CoA-transferase, subunit B
IPR012792 Domain 3-oxoacid CoA-transferase, subunit A

1 Cross References

Identifier
PIRSF000858

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0008410 IPR014388
GO:0046952 IPR014388

2 Ontology Annotations

GO Term Gene Name
GO:0008410 IPR014388
GO:0046952 IPR014388

1 Parent Features

DB identifier Type Name
IPR004165 Family Coenzyme A transferase family I

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1006668m.p PAC:33607270 Brachypodium distachyon Pangenome 439  
Brdisv1pangenome1006159m.p PAC:33621377 Brachypodium distachyon Pangenome 448  
Brdisv1BdTR11A1037346m.p PAC:35685902 Brachypodium distachyon BdTR11a 448  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11749953
            10409616