Protein Domain : IPR005494

Type:  Domain Name:  Glutathionylspermidine synthase, pre-ATP-grasp-like domain
Description:  Glutathionylspermidine (GSP) synthetases of Trypanosomatidae and Escherichia coli couple hydrolysis of ATP (to ADP and Pi) with formation of an amide bond between spermidine and the glycine carboxylate of glutathione (gamma-Glu-Cys-Gly). In the pathogenic trypanosomatids, this reaction is the penultimate step in the biosynthesis of the antioxidant metabolite, trypanothione (N1,N8-bis-(glutathionyl)spermidine), and is a target for drug design []. This domain, which is structurally related to the pre-ATP grasp domain, probably carries the substrate-binding site []. Short Name:  GSPS_pre-ATP-grasp-like_dom
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0 Child Features

0 Contains

1 Cross References

Identifier
PF03738

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR016185 Domain Pre-ATP-grasp domain

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1007639m.p PAC:33655849 Brachypodium distachyon Pangenome 620  
Brdisv1BdTR11A1048344m.p PAC:35690490 Brachypodium distachyon BdTR11a 825  
Brdisv1BdTR11A1040191m.p PAC:35689190 Brachypodium distachyon BdTR11a 620  
Zosma07g03320 PAC:50101930 Zostera marina 1014  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7775463
            17124497