Protein Domain : IPR005914

Type:  Family Name:  Acetoacetyl-CoA synthase
Description:  Isoprenoids are a large class of compounds, with more than 20,000 structures currently known, which are found in all living organisms. Some play essential physiological roles, such as sterols that stabilise cell membranes or carotenoids involved in photosynthesis, while the function of many others is not well understood. In all eukaryotes and some prokaryotes, isoprenoids are synthesised by the mevalonate pathway, while most prokaryotes use a mevalonate-independent pathway [, ].This entry represents acetoacetyl-CoA synthase (), catalysing the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA A Sinorhizobium protein in this entry is also required for growth on polyhydroxybutyrate, a commonly used carbon storage molecule in bacteria []. Short Name:  Acac_CoA_synth
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0 Child Features

2 Contains

DB identifier Type Name
IPR000873 Domain AMP-dependent synthetase/ligase
IPR020845 Conserved_site AMP-binding, conserved site

1 Cross References

Identifier
TIGR01217

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0030729 IPR005914
GO:0006629 IPR005914

2 Ontology Annotations

GO Term Gene Name
GO:0030729 IPR005914
GO:0006629 IPR005914

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1007785m.p PAC:33622473 Brachypodium distachyon Pangenome 650  
Brdisv1pangenome1009978m.p PAC:33623581 Brachypodium distachyon Pangenome 651  
Brdisv1BdTR11A1042849m.p PAC:35696720 Brachypodium distachyon BdTR11a 650  
Brdisv1BdTR11A1040759m.p PAC:35689114 Brachypodium distachyon BdTR11a 651  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15604784
            8240251
            10735852