Protein Domain : IPR015868

Type:  Family Name:  Glutaminase
Description:  Glutaminases () deaminate glutamine to glutamate. In Bacillus subtilis, glutaminase is encoded by glnA, which is part of an operon, glnA-glnT (formerly ybgJ-ybgH), where glnT encodes a glutamine transporter. The glnA-glnT operon is regulated by the 2-component system GlnK-GlnL in response to glutamine []. This entry represents the core structural motif of a family of glutaminases that include GlnA, which are characterised by their beta-lactamase-like topology, containing a cluster of alpha-helices and an alpha/beta sandwich.This family describes the enzyme glutaminase, from a larger family that includes serine-dependent beta-lactamases and penicillin-binding proteins. Many bacteria have two isozymes. This model is based on selected known glutaminases and their homologues within prokaryotes, with the exclusion of highly-derived (long branch) and architecturally varied homologues, so as to achieve conservative assignments. A sharp drop in scores occurs below 250, and cutoffs are set accordingly. The enzyme converts glutamine to glutamate, with the release of ammonia. Members tend to be described as glutaminase A (glsA), where B (glsB) is unknown and may not be homologous (as in Rhizobium etli. Some species have two isozymes that may both be designated A (GlsA1 and GlsA2). Short Name:  Glutaminase
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0 Child Features

1 Contains

DB identifier Type Name
IPR012338 Domain Beta-lactamase/transpeptidase-like

4 Cross Referencess

Identifier
PTHR12544
PF04960
TIGR03814
MF_00313

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004359 IPR015868
GO:0006541 IPR015868

2 Ontology Annotations

GO Term Gene Name
GO:0004359 IPR015868
GO:0006541 IPR015868

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1008338m.p PAC:33624173 Brachypodium distachyon Pangenome 293  
Brdisv1pangenome1010529m.p PAC:33657873 Brachypodium distachyon Pangenome 505  
Brdisv1pangenome1011458m.p PAC:33619563 Brachypodium distachyon Pangenome 356  
Brdisv1BdTR11A1043923m.p PAC:35689246 Brachypodium distachyon BdTR11a 293  
Brdisv1BdTR11A1040017m.p PAC:35694985 Brachypodium distachyon BdTR11a 505  
Brdisv1BdTR11A1041225m.p PAC:35692584 Brachypodium distachyon BdTR11a 356  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15995196