Protein Domain : IPR011265

Type:  Family Name:  GABA permease
Description:  GABA permease (gabP) catalyses the translocation of 4-aminobutyrate (GABA) across the plasma membrane, with homologues expressed in Gram-negative and Gram-positive organisms. This permease is a highly hydrophobic transmembrane protein consisting of 12 transmembrane domains with hydrophilic N- and C-terminal ends []. Induced by nitrogen-limited culture conditions in both Escherichia coliand Bacillus subtilis, gabP is an energy dependent transport system stimulated by membrane potential and has been observed adjacent and distant from other GABA degradation proteins [, ]. GabP is highly homologous to amino acid permeases from B. subtilis, E. coli, as well as to other members of the amino acid permease family (). A member of the APC (amine-polyamine-choline) transporter superfamily, GABA permease possesses a "consensus amphiphatic region" (CAR) found to be evolutionarily conserved within this transport family []. This amphiphatic region is located between helix 8 and cytoplasmic loop 8-9, forming a potential channel domain and suggested to play a significant role in ligand recognition and translocation []. Unique to GABA permeases, a conserved cysteine residue (CYS-300, E. coli) located at the beginning of the amphiphatic domain, has been determined to be critical for catalytic specificity []. Short Name:  GABA_permease
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0 Child Features

1 Contains

DB identifier Type Name
IPR004840 Conserved_site Amino acid permease, conserved site

1 Cross References

Identifier
TIGR01773

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0015185 IPR011265
GO:0015812 IPR011265
GO:0016021 IPR011265

3 Ontology Annotations

GO Term Gene Name
GO:0015185 IPR011265
GO:0015812 IPR011265
GO:0016021 IPR011265

1 Parent Features

DB identifier Type Name
IPR002293 Family Amino acid/polyamine transporter I

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1008432m.p PAC:33656483 Brachypodium distachyon Pangenome 729  
Brdisv1BdTR11A1044145m.p PAC:35689064 Brachypodium distachyon BdTR11a 729  
Brdisv1BdTR11A1040991m.p PAC:35695132 Brachypodium distachyon BdTR11a 720  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8297211
            9677314
            9685361