Protein Domain : IPR004220

Type:  Family Name:  5-carboxymethyl-2-hydroxymuconate isomerase
Description:  5-carboxymethyl-2-hydroxymuconate isomerase transforms 5-carboxymethyl-2-hydroxy-muconic acid into 5-oxo-pent-3-ene-1,2,5-tricarboxylic acid during the third step of the homoprotocatechuate catabolic pathway []. Homoprotocatechuate (HPC; 3,4-dihydroxyphenylacetate) is catabolized to Krebs cycle intermediates via extradiol (meta-) cleavage and the necessary enzymes are chromosomally encoded in a variety of bacteria []. 5-carboxymethyl-2-hydroxymuconate isomerase is probably a dimer of two identical subunits []. A comparison of the N-terminal half of the isomerase/decarboxylase sequence from the pathway (both encoded by the gene hpcE), with the second half showed significant similarity. This suggests that a duplication may have occurred to produce a bifunctional gene []. Short Name:  5-COMe_2-OHmuconate_Isoase
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0 Child Features

0 Contains

1 Cross References

Identifier
PF02962

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0008704 IPR004220
GO:0019439 IPR004220

2 Ontology Annotations

GO Term Gene Name
GO:0008704 IPR004220
GO:0019439 IPR004220

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1008798m.p PAC:33656646 Brachypodium distachyon Pangenome 477  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8223600
            2194841
            8384293