Protein Domain : IPR001859

Type:  Family Name:  Trypanosoma cruzi ribosomal protein P2-like
Description:  Eukaryotic ribosomal P proteins have been classified according to their similarity to the mammalian P0, P1 and P2 proteins [], all of which share a similar primary structure: an apparently globular N-terminal domain (which includes the protein core); an Ala-rich hinge region; and a highly-acidic Glu/Asp-rich C-terminal domain - this contains the ribosomal P consensus sequence EESDDDMGFGLFD, which protrudes from the ribosomal stalk.The C-terminal regions of Trypanosoma cruziP proteins are strongly immunogenic in Chagas disease. All 3 forms of the protein show the ability to generate autoimmune responses, but their antigenic properties differ as a result of discrepancies in their C-terminal sequences []. The main linear epitope of the T. cruzi P1 and P2 proteins has been mapped to the 13-residue C-terminal sequence (R-13) EEEDDDMGFGLFD. This is identical to the eukaryotic P consensus, but has Ser substituted by Glu, yielding a more hydrophilic sequence, which is critical in determining the immunological reactivity of the T. cruzi R-13 epitope in Chagas disease.This entry represents a family of T.cruzi P2 ribosomal proteins. It also matches P2 proteins from different organisms or closely-related ribosomal P1 proteins. Short Name:  T.cruzi_P2-like
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0 Child Features

0 Contains

1 Cross References

Identifier
PR00456

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003735 IPR001859
GO:0006412 IPR001859
GO:0005622 IPR001859
GO:0005840 IPR001859

4 Ontology Annotations

GO Term Gene Name
GO:0003735 IPR001859
GO:0006412 IPR001859
GO:0005622 IPR001859
GO:0005840 IPR001859

1 Parent Features

DB identifier Type Name
IPR027534 Family Ribosomal protein L12 family

86 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Lus10008943 PAC:23175153 Linum usitatissimum 111  
Lus10008944 PAC:23175186 Linum usitatissimum 111  
Lus10028876 PAC:23177192 Linum usitatissimum 111  
Potri.014G063400.1 A0A2K1XRA8 PAC:27033227 Populus trichocarpa 242  
27612 A4S7T7 PAC:27419638 Ostreococcus lucimarinus 112  
Migut.F00149.1.p PAC:28931690 Mimulus guttatus 112  
Glyma.04G229000.1.p I1JYI8 PAC:30490429 Glycine max 110  
Cre17.g702052.t1.1 A0A2K3CP18 PAC:30781854 Chlamydomonas reinhardtii 71  
SapurV1A.0250s0020.1.p PAC:31441860 Salix purpurea 110  
Traes_7AL_A1EA63AD2.1 PAC:32000911 Triticum aestivum 90  
Pahal.F00152.3 A0A2S3HZN9 PAC:32487818 Panicum hallii 109  
Pahal.F00152.4 A0A2S3HZN9 PAC:32487819 Panicum hallii 109  
Pahal.F00152.2 A0A2S3HZN9 PAC:32487817 Panicum hallii 109  
Pahal.F00152.1 A0A2S3HZN9 PAC:32487816 Panicum hallii 109  
Kalax.0022s0001.1.p PAC:32570820 Kalanchoe laxiflora 110  
Sevir.6G085100.1.p A0A4U6U381 PAC:32644358 Setaria viridis 109  
Seita.2G097600.1.p A0A368PXJ9 PAC:32720480 Setaria italica 135  
Seita.6G085600.1.p A0A368RJE1 PAC:32699277 Setaria italica 109  
Pp3c14_7080V3.1.p A9U0Z9 PAC:32960286 Physcomitrium patens 115  
Pp3c14_7080V3.2.p A9U0Z9 PAC:32960287 Physcomitrium patens 115  
Pp3c2_15480V3.1.p A9RV72 PAC:32933822 Physcomitrium patens 114  
Pp3c2_15480V3.2.p A9RV72 PAC:32933823 Physcomitrium patens 114  
Pp3c6_20310V3.2.p A9RKJ0 PAC:32976467 Physcomitrium patens 114  
Pp3c6_20310V3.1.p A9RKJ0 PAC:32976466 Physcomitrium patens 114  
Aco004712.1 PAC:33053858 Ananas comosus 229  
Kaladp0067s0213.1.p PAC:35776145 Kalanchoe fedtschenkoi 110  
Kaladp0067s0213.2.p PAC:35776146 Kalanchoe fedtschenkoi 110  
Oropetium_20150105_24436A PAC:36007547 Oropetium thomaeum 134  
Oropetium_20150105_13742A PAC:35998937 Oropetium thomaeum 109  
Phvul.005G126000.1.p V7BVP3 PAC:37153535 Phaseolus vulgaris 112  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15463674