Protein Domain : IPR011031

Type:  Domain Name:  Multihaem cytochrome
Description:  In proteins belonging to the c-type cytochrome family [], the haem group is covalently attached by thioether bonds to two conserved cysteine residues located in the cytochrome c centre. Cytochromes c typically function in electron transfer, but c-type cytochrome centres are also found in the active sites of many enzymes.This domain contains multiple CxxCH motifs. There are a variable number of helices, as well as a little beta structure present in multihaem cytochromes, but they do not form a true structural fold. Cytochrome (cyt) c3-like proteins are multihaem cytochromes, including cyt c3 with four haem groups [], cyt c7 (cyt c551.5) with three haem groups (deletion of one cyt c3 haem-binding site), nine-haem cyt c (tandem repeat of two cyt c3-like domains with an additional haem-binding site), and 16-haem cyt c HmcA (tandem repeat of four cyt c3-like domains). The photosynthetic reaction centre composed of a cytochrome subunit is also a multihaem cytochrome []. In addition, the di-haem elbow motif shows a similar structure, the main characteristic feature of this motif being the packing of its two haems; many members of this group of proteins contain one or more complete motifs flanked by incomplete motifs and/or other domains. For example, the di-haem elbow motif is present in the multihaem cytochrome domain found in the periplasmic nitrate reductase subunit NapB [], in hydroxylamine oxioreductase HAO (contains 3 complete motifs), in cyt c554 (contains one complete motif), in cyt c nitrite reductase, and in the N-terminal domain of flavocytochrome c3 (respiratory fumarate reductase). Short Name:  Multihaem_cyt
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4 Child Features

DB identifier Type Name
IPR023155 Domain Cytochrome c-552/4
IPR005126 Domain NapC/NirT cytochrome c, N-terminal
IPR010177 Domain Doubled CXXCH motif
IPR020942 Domain Class III cytochrome C

2 Contains

DB identifier Type Name
IPR010176 Repeat CxxxxCH...CXXCH motif, Geobacter sulfurreducens
IPR010177 Domain Doubled CXXCH motif

1 Cross References

Identifier
PS51008

9 Found Ins

DB identifier Type Name
IPR002322 Family Cytochrome c, class III
IPR011346 Family High-molecular-weight cytochrome c
IPR012138 Family Hydroxylamine oxidase
IPR009154 Family Membrane-bound tetrahaem cytochrome TorC/YecK
IPR017564 Family Cytochrome c nitrite reductase, pentahaem subunit
IPR005591 Family Nitrate reductase cytochrome c-type subunit NapB
IPR017570 Family Formate-dependent cytochrome c nitrite reductase, c552 subunit
IPR003321 Family Cytochrome c552
IPR003158 Family Photosynthetic reaction centre, cytochrome c subunit

0 GO Annotation

0 Ontology Annotations

0 Parent Features

79 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Potri.015G078300.1 PAC:27018701 Populus trichocarpa 997  
Potri.015G078300.3 PAC:27018702 Populus trichocarpa 941  
Potri.015G078300.2 PAC:27018703 Populus trichocarpa 888  
Potri.004G104200.1 A0A2K2ASQ9 PAC:26989155 Populus trichocarpa 625  
Migut.J01302.2.p PAC:28940852 Mimulus guttatus 193  
Migut.J01302.1.p PAC:28940853 Mimulus guttatus 193  
Migut.B01459.1.p PAC:28946938 Mimulus guttatus 606  
Migut.B01457.1.p PAC:28947528 Mimulus guttatus 505  
Araha.14781s0002.1.p PAC:28861352 Arabidopsis halleri 425  
SapurV1A.0011s0190.1.p PAC:31430901 Salix purpurea 1072  
SapurV1A.0726s0110.1.p PAC:31430021 Salix purpurea 1488  
SapurV1A.0726s0110.2.p PAC:31430022 Salix purpurea 1465  
SapurV1A.0726s0110.3.p PAC:31430023 Salix purpurea 1465  
SapurV1A.0726s0110.4.p PAC:31430024 Salix purpurea 1465  
GSMUA_Achr1P25510_001 PAC:32314232 Musa acuminata 1026  
Seita.2G142000.1.p A0A368PYZ7 PAC:32721689 Setaria italica 350  
Zosma58g00500.1 A0A0K9NV01 PAC:33180773 Zostera marina 1762  
Zosma721g00050.1 A0A0K9NQP8 PAC:33183466 Zostera marina 901  
Dusal.0270s00010.1.p PAC:33189992 Dunaliella salina 626  
AUR62014546-RA PAC:36304491 Chenopodium quinoa 1451  
Potri.004G104200.1.p A0A2K2ASQ9 PAC:37231862 Populus trichocarpa 625  
Potri.015G078250.1.p A0A3N7G1P7 PAC:37254562 Populus trichocarpa 508  
Podel.15G082000.1.p PAC:37295022 Populus deltoides WV94 508  
Podel.15G082000.2.p PAC:37295023 Populus deltoides WV94 399  
Podel.04G114100.2.p PAC:37290060 Populus deltoides WV94 1463  
Podel.04G114100.1.p PAC:37290059 Populus deltoides WV94 1463  
Oeu016401.1 PAC:37734950 Olea europaea 968  
evm.model.Scaffold_105.160 PAC:37899288 Coffea arabica 1088  
evm.model.Scaffold_1202.11 PAC:37871432 Coffea arabica 1092  
AH002500-RA PAC:38181803 Amaranthus hypochondriacus 1165  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11095707
            3881803
            11551953
            11939777