| Type: | Domain | Name: | Catenin binding domain |
| Description: | This entry represents the catenin binding domain. Proteins containing this domain include cadherins, desmocollins, desmoglein and transcription factor 7-like proteins [, , , ].Cadherins and catenins play important roles in the adherens junctions in animal cells. The cadherin-catenin complex is responsible for coupling Ca(2+)-dependent intercellular junctions with actin dynamics and signaling pathways. Desmosomal cadherins are TM protein components of desmosomes (for review, see [, , )],whose extracellular cadherin repeats are responsible for adhesion and whose intracellular regions interact with intermediate filaments via desmosomalplaque proteins plakoglobin, plakobilin and desmoplakin. They are believed to play a wider role in regulation of epithelial differentiation[]. Two sub-families of desmosomal cadherin have been identified,desmocollin (DSC) and desmoglein (DSG). | Short Name: | Catenin_binding_dom |
