Type: | Family | Name: | Kinetochore component CENP-S |
Description: | CENP-S is a dual function protein. It aids DNA repair/recombination and localises to centromeres to promote chromosome segregation []. It is a kinetochore component that forms complexes with CENP-X to form a stable CENP-T-W-S-X heterotetramer [, ]. CENP-S (also known as MHF1) is also a component of the FA complex, which is involved in DNA damage repair and genome maintenance [, ]. This entry also includes Blood-induced peptide 1 (BLP1) from Candida albicans. It plays an important role in survival in host blood through increasing tolerance to stresses such as heat, salt, or cycloheximide, which is essential for virulence []. | Short Name: | CENP-S |