Protein Domain : IPR005632

Type:  Family Name:  Chaperone protein Skp
Description:  The 17kDa protein Skp (also known as OmpH) of Escherichia coliis a homotrimeric periplasmic chaperone for newly synthesised outer-membrane proteins, the X-ray structure of which has been reported at resolutions of 2.35 A and 2.30 A [, ]. Three hairpin-shaped alpha-helical extensions reach out by approximately 60 A from a trimerisation domain, which is composed of three intersubunit beta-sheets that wind around a central axis. The alpha-helical extensions approach each other at their distal turns, resulting in a fold that resembles a 'three-pronged grasping forcep'. The overall shape of Skp is reminiscent of the cytosolic chaperone prefoldin (), although it is based on a radically different topology. The peculiar architecture, with apparent plasticity of the prongs and distinct electrostatic and hydrophobic surface properties, supports the recently proposed biochemical mechanism of this chaperone: formation of a Skp(3)-Omp complex protects the outer membrane protein from aggregation during passage through the bacterial periplasm.The ability of Skp to prevent the aggregation of model substrates in vitro is independent of ATP. Skp can interact directly with membrane lipids and lipopolysaccharide. These interactions are needed for efficient Skp-assisted folding of membrane proteins [].The Haemophilus influenzae member of the family, OMP26, is an outer membrane protein that shows significant potential as a vaccine candidate []. It is not clear if this protein has undergone adaptive changes in H. influenzae so as to locate to the outer membrane, or if Skp proteins are to some extent peripherally associated with the outer membrane in all species. Short Name:  Chaperone_Skp
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF03938
PIRSF002094
SM00935

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0051082 IPR005632

1 Ontology Annotations

GO Term Gene Name
GO:0051082 IPR005632

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Gorai.001G012500.2 A0A0D2PT86 PAC:26824564 Gossypium raimondii 366  
Solyc00g130810.1.1 PAC:36128245 Solanum lycopersicum 143  
Solyc00g130810.1.1 PAC:41467517 Solanum lycopersicum 143  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15304217
            15361861
            10085039