Protein Domain : IPR001273

Type:  Family Name:  Aromatic amino acid hydroxylase
Description:  Phenylalanine, tyrosine and tryptophan hydroxylases constitute a family of tetrahydrobiopterin-dependent aromatic amino acid hydroxylases, all of which are rate-limiting catalysts for important metabolic pathways []. The proteins are structurally and functionally related, each containing iron, and catalysing ring hydroxylation of aromatic amino acids, using tetra-hydrobiopterin (BH4) as a substrate. All are regulated by phosphorylation at serines in their N-termini. It has been suggested that the proteins each contain a conserved C-terminal catalytic (C) domain and an unrelated N-terminal regulatory (R) domain. It is possible that the R domains arose from genes that were recruited from different sources to combine with the common gene for the catalytic core. Thus, by combining with the same C domain, the proteins acquiredthe unique regulatory properties of the separate R domains.A variety of enzymes belong to this family that includes, phenylalanine-4-hydroxylase from Chromobacterium violaceumwhere it is copper-dependent; it is iron-dependent in Pseudomonas aeruginosa, phenylalanine-4-hydroxylase catalyzes the conversion of phenylalanine to tyrosine. In humans, deficiencies are the cause of phenylketonuria, the most common inborn error of amino acid metabolism [], tryptophan 5-hydroxylase catalyzes the rate-limiting step in serotonin biosynthesis: the conversion of tryptophan to 3-hydroxy-anthranilate and tyrosine 3-hydroxylase catalyzes the rate limiting step in catecholamine biosynthesis: the conversion of tyrosine to 3,4-dihydroxy-L-phenylalanine. Short Name:  ArAA_hydroxylase
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2 Child Features

DB identifier Type Name
IPR019773 Family Tyrosine 3-monooxygenase-like
IPR005960 Family Phenylalanine-4-hydroxylase, monomeric form

3 Contains

DB identifier Type Name
IPR019774 Domain Aromatic amino acid hydroxylase, C-terminal
IPR018301 Binding_site Aromatic amino acid hydroxylase, iron/copper binding site
IPR021164 Conserved_site Tyrosine hydroxylase, conserved site

2 Cross Referencess

Identifier
PTHR11473
G3DSA:1.10.800.10

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004497 IPR001273
GO:0005506 IPR001273
GO:0009072 IPR001273
GO:0055114 IPR001273

4 Ontology Annotations

GO Term Gene Name
GO:0004497 IPR001273
GO:0005506 IPR001273
GO:0009072 IPR001273
GO:0055114 IPR001273

0 Parent Features

129 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_134.7 PAC:16408234 Carica papaya 127  
evm.model.supercontig_38.37 PAC:16418872 Carica papaya 59  
16625 I0YV42 PAC:27385850 Coccomyxa subellipsoidea C-169 305  
Thecc1EG016205t1 A0A061G688 PAC:27450777 Theobroma cacao 313  
Araha.6046s0002.3.p PAC:28850243 Arabidopsis halleri 54  
Araha.6046s0002.5.p PAC:28850244 Arabidopsis halleri 54  
Araha.6046s0002.4.p PAC:28850241 Arabidopsis halleri 54  
Araha.6046s0002.2.p PAC:28850242 Arabidopsis halleri 54  
Araha.6046s0002.1.p PAC:28850245 Arabidopsis halleri 54  
Araha.6046s0002.6.p PAC:28850246 Arabidopsis halleri 54  
Bostr.29223s0071.1.p PAC:30676956 Boechera stricta 114  
Bostr.23794s0064.1.p PAC:30651145 Boechera stricta 293  
Cre01.g029250.t1.2 A8HQD7 PAC:30789244 Chlamydomonas reinhardtii 361  
Bradi3g58222.1.p PAC:31153343 Brachypodium distachyon 156  
Traes_5AL_5CC3E90EE.1 PAC:31930686 Triticum aestivum 250  
Prupe.7G205700.3.p A0A251NEJ6 PAC:32103087 Prunus persica 268  
Kalax.0183s0026.1.p PAC:32563424 Kalanchoe laxiflora 811  
Sphfalx0159s0009.1.p PAC:32627840 Sphagnum fallax 410  
Seita.3G209700.1.p K3ZD52 PAC:32710219 Setaria italica 398  
Pp3c25_2670V3.1.p A0A2K1IDK6 PAC:32980505 Physcomitrium patens 174  
Pp3c25_2670V3.11.p PAC:32980515 Physcomitrium patens 169  
Pp3c25_2670V3.12.p PAC:32980516 Physcomitrium patens 169  
Pp3c25_2670V3.9.p PAC:32980513 Physcomitrium patens 169  
Pp3c25_2670V3.6.p PAC:32980510 Physcomitrium patens 169  
Pp3c26_5689V3.1.p A0A2K1IBY0 PAC:32917984 Physcomitrium patens 63  
Pp3c8_13930V3.2.p E5KBU4 PAC:32966237 Physcomitrium patens 394  
Pp3c8_13930V3.1.p E5KBU4 PAC:32966236 Physcomitrium patens 394  
Pp3c8_13930V3.4.p E5KBU4 PAC:32966239 Physcomitrium patens 394  
Pp3c8_13930V3.3.p E5KBU4 PAC:32966238 Physcomitrium patens 394  
LOC_Os01g66230.1 PAC:33119611 Oryza sativa 384  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9406548
            3475690