Type: | Family | Name: | Membrane-anchored ubiquitin-fold protein, HCG-1 |
Description: | Ubiquitin-fold proteins are an important class of eukaryotic post-translational modifiers [, ]. They are generally short proteins (less than 200 amino acids) which contain the core beta-grasp fold (also known as the ubiquitin fold) and a C-terminal extension which enables their attachment to other proteins through the terminal carboxyl group. Protein-conjugated ubiquitins have been implicated an a wide variety of cellular process including proteolysis, DNA repair, transcription and autophagy Some ubiquitin-like proteins are not conjugated to proteins, but are instead anchored to the cell membrane by attachment to phospholipids or isoprenes. The functions of these membrane-associated proteins are not generally well understood. In the case of isoprene attachemnet, the prenyl group may also play a role in enhancing protein-protein interactions.This entry represents a group of membrane-associated ubiquitin-fold proteins found in plants and animals []. Despite a low level of sequence smilarity to other ubiquitin-fold proteins, the Arabidopsis MUB1 protein in this entry has been shown to adopt the core beta-grasp fold along with the typical C-terminal extension []. The Arabidopsis proteins in this entry are prenylated in vivo and are preferentially located at the plasma membrane. The functions of these proteins are not known, though their conservation in higher eukaryotes suggests they may play an important role within the cell. | Short Name: | M-anchored_Ub-fold_HCG-1 |