| Type: | Domain | Name: | SOCS box domain |
| Description: | The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family [] but was later also found in:the WSB (WD-40-repeat-containing proteins with a SOCS box) family,the SSB (SPRY domain-containing proteins with a SOCS box) family,the ASB (ankyrin-repeat-containing proteins with a SOCS box) family,and ras and ras-like GTPases [].The SOCS box found in these proteins is an about 50 amino acid carboxy-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues []. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box [], which binds to the Elongin BC complex [, ]. It has been proposed that this association could couple bound proteins to the ubiquitination or proteasomal compartments []. | Short Name: | SOCS_box |
