Protein Domain : IPR000716

Type:  Domain Name:  Thyroglobulin type-1
Description:  Thyroglobulin (Tg) is a large glycoprotein specific to the thyroid gland and is the precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The N-terminal section of Tg contains 10 repeats of a domain of about 65 amino acids which is known as the Tg type-1 repeat [, ]. Such a domain has also been found as a single or repeated sequence in the HLA class II associated invariant chain []; human pancreatic carcinoma marker proteins GA733-1 and GA733-2 []; nidogen (entactin), a sulphated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin; insulin-like growth factor binding proteins (IGFBP) []; saxiphilin, a transferrin-like protein from Rana catesbeiana(Bull frog) that binds specifically to the neurotoxin saxitoxin []; chum salmon egg cysteine proteinase inhibitor, and equistatin, a thiol-protease inhibitor from Actinia equina(sea anemone) []. The existence of Thyr-1 domains in such a wide variety of proteins raises questions about their activity and function, and their interactions with neighbouring domains. The Thyr-1 and related domains belong to MEROPS proteinase inhibitor family I31, clan IX.Equistatin from A. equina is composed of three Thyr-1 domains; as with other proteins that contains Thyr-1 domains, the thyropins, they bind reversibly and tightly to cysteine proteases (inhibitor family C1). In equistatin inhibition of papain is a function of domain-1. Unusually domain-2 inhibits cathepsin D, an aspartic protease (inhibitor family A1) and has no activity against papain. Domain-3, does not inhibit either papain or cathepsin D, and its function or its target peptidase has yet to be determined [, ]. Short Name:  Thyroglobulin_1
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0 Child Features

0 Contains

6 Cross Referencess

Identifier
PF00086
PS00484
PS51162
SM00211
G3DSA:4.10.800.10
SSF57610

10 Found Ins

DB identifier Type Name
IPR016324 Family Thyroglobulin
IPR012210 Family Insulin-like growth factor binding protein 2
IPR022321 Family Insulin-like growth factor-binding protein family 1-6, chordata
IPR012213 Family Insulin-like growth factor binding protein 5
IPR012211 Family Insulin-like growth factor binding protein 3
IPR022322 Family Insulin-like growth factor-binding protein 1
IPR022326 Family Insulin-like growth factor-binding protein 6
IPR022327 Family Insulin-like growth factor-binding protein 4
IPR022339 Family MHC class II-associated invariant chain
IPR009168 Family Insulin-like growth factor binding protein

0 GO Annotation

0 Ontology Annotations

0 Parent Features

124 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Gorai.009G115800.7 A0A0D2RYS6 PAC:26771489 Gossypium raimondii 291  
Thecc1EG005008t1 A0A061DT07 PAC:27434754 Theobroma cacao 338  
Thecc1EG011478t1 A0A061E9L1 PAC:27464760 Theobroma cacao 240  
Araha.3578s0003.1.p PAC:28844041 Arabidopsis halleri 123  
Bostr.3053s0019.1.p PAC:30659371 Boechera stricta 59  
Medtr4g098710.1 G7JHL7 PAC:31106509 Medicago truncatula 81  
Medtr0538s0030.1 PAC:31105885 Medicago truncatula 76  
Medtr0538s0010.1 PAC:31105886 Medicago truncatula 76  
evm_27.model.AmTr_v1.0_scaffold00183.10 U5D398 PAC:31560542 Amborella trichopoda 119  
Traes_3B_D5D707322.3 PAC:31835937 Triticum aestivum 272  
Traes_6BS_98B1DAFB9.1 PAC:31766663 Triticum aestivum 599  
Traes_6BS_98B1DAFB9.3 PAC:31766665 Triticum aestivum 538  
Traes_6BS_98B1DAFB9.2 PAC:31766664 Triticum aestivum 599  
GSMUA_Achr9P10350_001 PAC:32308412 Musa acuminata 1207  
GSMUA_Achr9P29310_001 PAC:32308278 Musa acuminata 164  
Bradi3g26498.1.p A0A0Q3FEQ6 PAC:32813721 Brachypodium distachyon 125  
LOC_Os08g37860.1 PAC:33107288 Oryza sativa 267  
Brdisv20Bd21Ref1029305m.p A0A0Q3FEQ6 PAC:33468642 Brachypodium distachyon Bd21 AnntCtrl 125  
Brdisv1pangenome1042523m.p A0A0Q3FEQ6 PAC:33626418 Brachypodium distachyon Pangenome 125  
Brdisv1Bd30-11030735m.p PAC:34051051 Brachypodium distachyon Bd30-1 102  
Brdisv1ABR81029504m.p PAC:34582165 Brachypodium distachyon ABR8 102  
Brdisv1Bd21Control1015815m.p PAC:34792748 Brachypodium distachyon Bd21 AsmbCtrl 407  
Brdisv1BdTR11I1044239m.p PAC:34917486 Brachypodium distachyon BdTR11i 283  
Brdisv1BdTR2G1014478m.p PAC:35065512 Brachypodium distachyon BdTR2g 283  
Brdisv1BdTR2B1015519m.p PAC:35481406 Brachypodium distachyon BdTR2b 334  
AL4G42480.t1 PAC:35925158 Arabidopsis lyrata 125  
Tp57577_TGAC_v2_mRNA29627 A0A2K3MYU4 PAC:35986397 Trifolium pratense 83  
AUR62038726-RA PAC:36285210 Chenopodium quinoa 661  
Phvul.005G185300.1.p V7BY36 PAC:37152496 Phaseolus vulgaris 653  
Zm00008a007565_P01 PAC:37204037 Zea mays PH207 63  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3038530
            3595599
            8797845
            1709161
            9153250
            2333300
            8146142
            12650938