| Type: | Domain | Name: | Calcineurin-like phosphoesterase C-terminal |
| Description: | This domain is found to the C terminus of Calcineurin-like phosphoesterase domains () in cAMP phosphodiesterases and the homologous Icc proteins []. YfcE, from Escherichia coli, belongs to a conserved protein family within the calcineurin-like phosphoesterase superfamily () that is widely distributed in bacteria and archaea []. The B-subunits of replicative DNA polymerases also belong to the superfamily of calcineurin-like phosphoesterases and are conserved from Archaea to humans. Since B-subunit sequences are very similar, it implies a common fold, however the key catalytic and metal binding residues of the phosphoesterase domain are disrupted in the eukaryotic beta-subunits. The C-terminal part of the protein contains both the calcineurin-like phosphoesterase domain and the OB-fold, which are sufficient for its nuclease activity [, ]. Calcineurin is also the conserved target of the immunosuppressants cyclosporin A and FK506 []. | Short Name: | Calcineurin-like_phos_C |
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| Brdisv1BdTR11A1040180m.p | PAC:35696863 | Brachypodium distachyon BdTR11a |
935
 |
|
| Sphfalx16G039900.2.p | PAC:41958009 | Sphagnum fallax |
589
|
