Protein Domain : IPR004569

Type:  Family Name:  Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ
Description:  Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the epsilon-amino group of an active site lysine residue on the enzyme. The alpha-amino group of the substrate displaces the lysine epsilon-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].In Escherichia coli, the pdx genes involved in vitamin B6 have been characterised [, , ]. This entry represents PdxJ, which catalyses the condensation of 1-amino-3-oxo-4-(phosphohydroxy)propan-2-one and 1-deoxy-D-xylulose-5-phosphate to form pyridoxine-5'-phosphate. The product of the PdxJ reaction is then oxidized by PdxH to pyridoxal 5'-phosphate. Short Name:  PyrdxlP_synth_PdxJ
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0 Child Features

0 Contains

4 Cross Referencess

Identifier
PF03740
TIGR00559
SSF63892
MF_00279

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0033856 IPR004569
GO:0008615 IPR004569
GO:0005737 IPR004569

3 Ontology Annotations

GO Term Gene Name
GO:0033856 IPR004569
GO:0008615 IPR004569
GO:0005737 IPR004569

0 Parent Features

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1BdTR11A1044270m.p PAC:35691181 Brachypodium distachyon BdTR11a 791  
Pavir.7KG415900.5.p PAC:37686978 Panicum virgatum 113  
Pavir.7KG415900.2.p PAC:37686976 Panicum virgatum 168  
Ibeam.0778s0006.1.p PAC:39772872 Iberis amara 86  
Pavir.7KG415900.2.p PAC:41572411 Panicum virgatum 168  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7748903
            15581583
            8690703
            15189147
            16763894
            17109392
            10225425
            15242009
            17344055