Protein Domain : IPR025835

Type:  Family Name:  Thiopurine S-methyltransferase
Description:  This family consists of thiopurine S-methyltransferase proteins from both eukaryotes and prokaryotes. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulphydryl compounds, including anticancer and immunosuppressive thiopurines []. Thiopurine is commonly used to suppress the immune system in the case of autoimmune disease, inflammatory bowel disease and to prevent transplanted organ rejection []. Thiopurine drugs can be toxic to cells but their effect can be mediated by the incorporation of thioguanine nucleotides into DNA []. Short Name:  Thiopurine_S-MeTrfase
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1 Child Features

DB identifier Type Name
IPR022474 Family Thiopurine S-methyltransferase, Se/Te detoxification

0 Contains

2 Cross Referencess

Identifier
PIRSF023956
MF_00812

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0008119 IPR025835

1 Ontology Annotations

GO Term Gene Name
GO:0008119 IPR025835

1 Parent Features

DB identifier Type Name
IPR008854 Family TPMT family

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1BdTR11A1048764m.p PAC:35696265 Brachypodium distachyon BdTR11a 219  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9780226
            16207256
            15570193