| Type: | Domain | Name: | ApoC-II domain |
| Description: | This domain is found in apolipoprotein CII (apoC-II). ApoC-II is a surface constituent of plasma lipoproteins and the activator for lipoprotein lipase (LPL). It is therefore central for lipid transport in blood. Lipoprotein lipase is a key enzyme in the regulation of triglyceride levels in human serum []. It is the C-terminal helix of apoCII that is responsible for the activation of LPL []. The active peptide of apoC-II occurs at residues 44-79 and has been shown to reverse the symptoms of genetic apoC-II deficiency in a human subject [].Micellar SDS, a commonly used mimetic of the lipoprotein surface, inhibits the aggregation of apoC-II and induces a stable structure containing approximately 60% alpha-helix. The first 12 residues of apoC-II are structurally heterogeneous but the rest of the protein forms a predominantly helical structure []. | Short Name: | ApoC-II_domain |
