Protein Domain : IPR001083

Type:  Domain Name:  Copper fist DNA-binding domain
Description:  Some fungal transcription factors contain an N-terminal domain, the copper fist, which seems to be involved in copper-dependent DNA-binding [, ].These proteins activate the transcription of the metallothionein gene in response to copper. Metallothionein maintains copper levels in yeast [, ]. The copper fist domain, which is similar in structure to metallothionein itself, undergoes a large conformational change on copper-binding that allows DNA-binding. The domain contains a conserved array of zinc-binding residues (Cys-X2-Cys-X8-Cys-X-His) and forms a three-stranded antiparallel beta-sheet with two short helical segments that project from one end of the beta-sheet []. Conserved residues form a basic patch that may be important for DNA binding. Short Name:  Cu_fist_DNA-bd_dom
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0 Child Features

0 Contains

7 Cross Referencess

Identifier
PF00649
PR00617
PS01119
PS50073
SM00412
G3DSA:3.90.430.10
SSF57879

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR001083
GO:0003700 IPR001083
GO:0005507 IPR001083
GO:0006355 IPR001083
GO:0005634 IPR001083

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR001083
GO:0003700 IPR001083
GO:0005507 IPR001083
GO:0006355 IPR001083
GO:0005634 IPR001083

0 Parent Features

156 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_61.50 PAC:16423868 Carica papaya 97  
Gorai.013G185900.3 A0A0D2VFJ5 PAC:26786981 Gossypium raimondii 345  
Gorai.013G185900.2 A0A0D2VFJ5 PAC:26786980 Gossypium raimondii 345  
Gorai.007G345100.2 A0A0D2QHW8 PAC:26779907 Gossypium raimondii 360  
Gorai.007G345100.1 A0A0D2QHW8 PAC:26779906 Gossypium raimondii 360  
Thecc1EG034478t1 A0A061FLM2 PAC:27456410 Theobroma cacao 67  
Glyma.15G251200.1.p A0A0R0G5T4 PAC:30496610 Glycine max 350  
Medtr0003s0690.1 A0A072TLE0 PAC:31105806 Medicago truncatula 173  
Spipo2G0119100 PAC:31510532 Spirodela polyrhiza 90  
Traes_2AL_83950B6A9.6 PAC:31923313 Triticum aestivum 93  
Traes_3AS_8626B96B8.1 PAC:31820199 Triticum aestivum 86  
Traes_3DS_65349138C.3 PAC:31841266 Triticum aestivum 365  
Traes_3DS_65349138C.2 PAC:31841265 Triticum aestivum 365  
Traes_3DS_65349138C.4 PAC:31841267 Triticum aestivum 357  
Traes_3DS_65349138C.1 PAC:31841264 Triticum aestivum 378  
Eucgr.F04080.1.p A0A059BZ98 PAC:32056010 Eucalyptus grandis 97  
Prupe.1G049800.1.p A0A251QSP9 PAC:32120438 Prunus persica 146  
Prupe.1G153300.2.p M5XMB2 PAC:32110433 Prunus persica 119  
Prupe.1G153300.1.p M5XMB2 PAC:32110432 Prunus persica 119  
Manes.S027700.2.p A0A199UBI6 PAC:32339660 Manihot esculenta 247  
Manes.S027700.1.p A0A199UBS7 PAC:32339659 Manihot esculenta 264  
Pahal.G01741.1 PAC:32519105 Panicum hallii 85  
Pahal.C02128.1 PAC:32512808 Panicum hallii 422  
Sevir.2G202600.1.p A0A4U6VSX1 PAC:32636785 Setaria viridis 371  
Seita.9G571200.1.p A0A368SWX7 PAC:32692341 Setaria italica 80  
Aqcoe7G305500.1.p PAC:33070597 Aquilegia coerulea 198  
Brdisv1Bis-11035073m.p PAC:33791740 Brachypodium distachyon Bis-1 77  
Brdisv1Kah-11013753m.p PAC:34344615 Brachypodium distachyon Kah-1 238  
Kaladp0045s0367.1.p PAC:35781069 Kalanchoe fedtschenkoi 316  
Tp57577_TGAC_v2_mRNA20757 PAC:35974511 Trifolium pratense 517  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8262047
            8509391
            3052856
            9665167