Protein Domain : IPR003806

Type:  Domain Name:  ATP-grasp fold, DUF201-type
Description:  The ATP-grasp fold is one of several distinct ATP-binding folds, and is found in enzymes that catalyze the formation of amide bonds, catalyzing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule []. This fold is found in many different enzyme families, including various peptide synthetases, biotin carboxylase, synapsin, succinyl-CoA synthetase, pyruvate phosphate dikinase, and glutathione synthetase, amongst others []. These enzymes contribute predominantly to macromolecular synthesis, using ATP-hydrolysis to activate their substrates. The ATP-grasp fold shares functional and structural similarities with the PIPK (phosphatidylinositol phosphate kinase) and protein kinase superfamilies. The ATP-grasp domain consists of two subdomains with different alpha+beta folds, which grasp the ATP molecule between them. Each subdomain provides a variable loop that forms part of the active site, with regions from other domains also contributing to the active site, even though these other domains are not conserved between the various ATP-grasp enzymes [].This entry describes a type of ATP-grasp fold that is found in a set of proteins of unknown function. Short Name:  ATP-grasp_DUF201-type
Paste the following link

0 Child Features

1 Contains

DB identifier Type Name
IPR013816 Domain ATP-grasp fold, subdomain 2

1 Cross References

Identifier
PF02655

2 Found Ins

DB identifier Type Name
IPR016677 Family Uncharacterised conserved protein UCP016817, ATP-dependent carboligase
IPR011226 Family ATP-grasp family

2 GO Annotations

GO Term Gene Name
GO:0005524 IPR003806
GO:0046872 IPR003806

2 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR003806
GO:0046872 IPR003806

1 Parent Features

DB identifier Type Name
IPR011761 Domain ATP-grasp fold

10 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_66.90 PAC:16424659 Carica papaya 1924  
56342 I0YU26 PAC:27392174 Coccomyxa subellipsoidea C-169 506  
Cre13.g582800.t1.2 A0A2K3D0I5 PAC:30784524 Chlamydomonas reinhardtii 625  
Dusal.0037s00030.1.p PAC:33185956 Dunaliella salina 465  
Pum0424s0010.1.p A0A1X6NV98 PAC:38010978 Porphyra umbilicalis 566  
Cz08g25220.t1 PAC:38244794 Chromochloris zofingiensis 632  
Bobra.0203s0016.2.p PAC:40713898 Botryococcus braunii 629  
Bobra.0203s0016.1.p PAC:40713897 Botryococcus braunii 629  
Bobra.0164s0043.1.p PAC:40702864 Botryococcus braunii 597  
Vocar.0001s0118.1.p PAC:32884721 Volvox carteri 625  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7862655
            9416615
            12392708