Protein Domain : IPR001802

Type:  Family Name:  Mercuric transport protein periplasmic component/copper chaperone CopZ
Description:  This entry includes a group of metal binding proteins, including copper chaperone CopZ [] and mercuric transport protein periplasmic component MerP. They both contain a heavy-metal-associated (HMA) domain. CopZ is a chaperone that serves for the intracellular sequestration and transport of Cu+. It delivers Cu+ to the copper-exporting P-type ATPase A (CopA)[].MerP is a mercury scavenger that specifically binds to one mercury ion and which passes it to the mercuric reductase (MerA) via the MerT protein. The structure of the mercuric ion-binding protein MerP from Shigella flexnerihas been determined. The fold has been classed as a ferredoxin-like alpha-beta sandwich, having a beta-alpha beta-beta alpha-beta architecture, with the two alpha-helices overlaying a four-stranded anti-parallel beta-sheet []. Structural differences between the reduced and mercury-bound forms of merP are localised to the metal-binding loop containing the consensus sequence GMTCXXC, the two cysteines of which are involved in bi-coordination of Hg2+[]. Short Name:  MerP/CopZ
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1 Child Features

DB identifier Type Name
IPR011795 Family Mercuric transport protein periplasmic component

1 Contains

DB identifier Type Name
IPR017969 Conserved_site Heavy-metal-associated, conserved site

1 Cross References

Identifier
PR00946

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0046872 IPR001802

1 Ontology Annotations

GO Term Gene Name
GO:0046872 IPR001802

0 Parent Features

143 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_74.17 PAC:16425705 Carica papaya 942  
35210.m000025 B9TMX8 PAC:16826517 Ricinus communis 68  
orange1.1g042234m A0A067D4D7 PAC:18097138 Citrus sinensis 658  
Thhalv10010809m V4L5N7 PAC:20207700 Eutrema salsugineum 140  
Ciclev10018819m V4TMD3 PAC:20808634 Citrus clementina 868  
Potri.003G125600.2 PAC:26998823 Populus trichocarpa 708  
56356 PAC:27347643 Micromonas pusilla CCMP1545 1185  
Thecc1EG016237t1 A0A061G573 PAC:27449647 Theobroma cacao 988  
Migut.M02001.1.p A0A022RV73 PAC:28950228 Mimulus guttatus 992  
Migut.A00779.1.p A0A022Q6B7 PAC:28938662 Mimulus guttatus 991  
Glyma.03G086000.3.p A0A0R0KGF5 PAC:30515843 Glycine max 689  
Glyma.03G086000.5.p A0A0R0KQS1 PAC:30515842 Glycine max 713  
Glyma.03G086000.2.p K7KDU6 PAC:30515841 Glycine max 730  
Glyma.03G086000.4.p A0A0R0KLI8 PAC:30515840 Glycine max 913  
Glyma.03G086000.1.p I1JM65 PAC:30515839 Glycine max 954  
Glyma.19G140000.1.p I1N912 PAC:30511387 Glycine max 984  
Cre16.g682369.t1.1 A0A2K3CU24 PAC:30777742 Chlamydomonas reinhardtii 1187  
Medtr0644s0030.1 A0A072TFB1 PAC:31084799 Medicago truncatula 965  
evm_27.model.AmTr_v1.0_scaffold00022.359 W1PWM3 PAC:31552422 Amborella trichopoda 975  
evm_27.model.AmTr_v1.0_scaffold00032.280 U5D3X8 PAC:31559982 Amborella trichopoda 999  
Traes_6DS_26C5A0A44.6 PAC:31904935 Triticum aestivum 211  
Traes_6DS_26C5A0A44.7 PAC:31904936 Triticum aestivum 211  
Eucgr.D01863.1.p A0A059CHZ7 PAC:32050585 Eucalyptus grandis 898  
Eucgr.E00578.1.p A0A059C1M3 PAC:32030227 Eucalyptus grandis 986  
GSMUA_Achr5P12300_001 PAC:32326290 Musa acuminata 797  
GSMUA_Achr5P12280_001 PAC:32325575 Musa acuminata 207  
Manes.01G062700.1.p A0A2C9WKV2 PAC:32358438 Manihot esculenta 986  
Kalax.0139s0082.1.p PAC:32530554 Kalanchoe laxiflora 83  
Kalax.0199s0001.1.p PAC:32544236 Kalanchoe laxiflora 83  
Kalax.0027s0076.1.p PAC:32595929 Kalanchoe laxiflora 94  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9188683
            18048940