Type: | Domain | Name: | MutY, C-terminal |
Description: | Adenine DNA glycosylase (called MutY in bacteria and hMYH in humans) initiates repair of A-oxoG to C-G by removing the inappropriately paired adenine base from the DNA backbone. MutY belongs to a structural superfamily of proteins (the NUDIX hydrolase superfamily) that hydrolyse a wide range of organic pyrophosphates []. This entry represents the C-terminal domain of MutY. Its structure is similar to the NUDIX fold, which is an alpha/beta/alpha sandwich [, ]. | Short Name: | MutY_C |