Protein Domain : IPR011566

Type:  Family Name:  Ubiquinone biosynthesis protein Coq7
Description:  Coq7 (also known as Clk-1) is a di-iron carboxylate protein occuring in both prokaryotes and eukaryotes that is essential for ubiquinone biosynthesis [, ]. It has been implicated in the aging process as mutations in the Caenorhabditis elegans gene lead to increased lifespan []. Coq7 is a membrane-bound protein that functions as a monooxygenase to hydroxylate demethoxyubiquinone (2-methoxy-5-methyl-6-polyprenyl-1,4-benzoquinone) in the penultimate step of ubiquinone biosynthesis []. Biochemical studies indicate that NADH can serve directly as a reductant for catalytic activation of dioxygen and substrate oxidation by the enzyme, with no requirement for an additional reductase protein component []. This direct reaction with NADH is so far unique amongst members of the di-iron carboxylate protein family. Short Name:  Ubq_synth_Coq7
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1 Child Features

DB identifier Type Name
IPR023782 Family Ubiquinone biosynthesis protein Coq7, bacterial

1 Contains

DB identifier Type Name
IPR009078 Domain Ferritin-like superfamily

2 Cross Referencess

Identifier
PTHR11237
PF03232

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0006744 IPR011566
GO:0055114 IPR011566

2 Ontology Annotations

GO Term Gene Name
GO:0006744 IPR011566
GO:0055114 IPR011566

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
37106 I0YTL5 PAC:27392199 Coccomyxa subellipsoidea C-169 312  
Cre09.g401478.t1.1 A0A2K3DF26 PAC:30781389 Chlamydomonas reinhardtii 416  
Dusal.0039s00011.1.p PAC:33186935 Dunaliella salina 300  
Solyc00g030210.1.1 PAC:36127990 Solanum lycopersicum 1147  
Cz14g14080.t1 PAC:38243462 Chromochloris zofingiensis 162  
Bobra.0051s0055.1.p PAC:40715089 Botryococcus braunii 217  
Vocar.0061s0011.1.p PAC:32896724 Volvox carteri 338  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8621692
            9823893
            9020081
            11435415
            20923139